Magnesium is an essential mineral that plays a critical role in many physiological processes, including glucose metabolism. Magnesium deficiency is prevalent worldwide, and several studies have linked it to insulin resistance and type 2 diabetes. This review aims to explore the effect of magnesium deficiency on the incidence of insulin resistance and type 2 diabetes, as well as the potential mechanisms behind this association [1].
Magnesium and insulin resistance and type 2 diabetes
Insulin resistance is a condition in which cells become resistant to the effects of insulin, leading to elevated blood glucose levels. Several studies have shown that magnesium deficiency is associated with insulin resistance. Magnesium plays a crucial role in glucose metabolism, as it is required for the activation of insulin receptors and the transport of glucose into cells. Magnesium deficiency reduces insulin sensitivity, leading to impaired glucose uptake and increased insulin secretion. A meta-analysis of observational studies found that magnesium intake was inversely associated with the risk of type 2 diabetes, indicating that low magnesium intake may be a risk factor for insulin resistance and type 2 diabetes [2,3].