Alternative & Integrative Medicine

The neurological condition known as Parkinson's disease (PD) is progressive over time. It occurs as a result of the death of dopaminergic neurons. Two pathophysiological pathways for idiopathic Parkinson's disease are reactive oxygen species and complex I, which affects mitochondrial respiratory function. As a result, treating PD with natural antioxidants may offer a different treatment option that slows the disease's progression and avoids oxidative stress. In PD animal and cell line models, this review compares and discusses the outcomes of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea and Hypericum perforatum. The antioxidants under investigation have been shown to protect brain cells from oxidative damage in PD cell and animal models. However, there is always room for improvement and additional research regarding these phytochemicals' therapeutic value.

The Kshudra kustha type of Vicharchika is a common problem for Ayurvedic pediatric OPDs. This type of Vicharchika is characterized by the symptoms Kandu (itching), Srava (discharge), Pidaka (vesicles) and Shyava Varna (discoloration). Vata involvement is the cause of dry, blackish eczema lesions, Kapha involvement is the cause of itching in the affected areas and Pitta involvement is the cause of Srava. Vicharchika and eczema are more similar than not. At various points in the management of Kustha, the traditional texts of Ayurveda emphasize Shodhana and Shamana therapy as a treatment option. In children, Shamana treatment is preferable to Shodhana treatment. A clinical study was carried out with both inclusive and exclusive criteria to determine the efficacy of Durvadya Taila and Laghu Manjisthadi Kwatha in Vicharchika in children aged 5 to 16 years. For 45 days, patients received two doses of LaghuManjisthadi Kwatha and an external application of Durvadya Taila. After 15 days, they were contacted for follow-up care. The majority of patients (86.67 percent) in a group of 30 experienced significant improvement, 6.7% experienced complete remission and 6.67 percent experienced mild improvement. According to the clinical investigation, Durvadya Taila and Laghu Manjisthadi Kwatha are, without a doubt, safe and effective for treating Vicharchika in children.