Alternative & Integrative Medicine

Neuroblastoma is more frequent extra cranial childhood malignancy the goal of this study is evaluate pattern of neuroblastoma and 2 years survival in isfahan and comparison with others studies. The counted cases were 45 patients.25 of them were male (55.6%) and 20 of them were female (44.4%). Female/male ratio was 1.25. Primary sites of tumor in 32 patients were retroperitoan (71%), in 8 patients were posterior mediastineum 17.8%, in 3 patients were cervical 6.7% in pelvis 4.4%. In clinical manifestation the abdominal mass is predominant (17 patients 37.8%), abdominal pain in 6 patients 13.3%, abdominal distention in 2 patients (4.4%) fever in 6 patients (13.3%), cervical mass in 4 patients (6.7%), weight loss in 1 patient (2.2%). In evaluation of bone marrow biopsy 22 patient have metastasis to bone (48.8%) and 23 patients have not metastasis (51.1%). In evaluation of peripheral blood smear 29 patient have hypochrome RBC (64.4%) 32 patients have anisocytosis (71.1%), 30 patients have microcytosis (66.7%), 7 patients have low platelets (15.6%), 6 patients have high platelets 13.3%, 5 patients have lymphocytosis (11.1%), 7 patients have atypical lymphocyte (15.6%) 35 cases of them had died (77.8%), and 10 patients had been being alive (22.2%). Statistical analysis show us mean survival of patient with surgical process was 38.8 months and for patient without surgery was 30.6 months. Total 30 month survival in our study was 50%. Female/male ratio (1.25) in our study is same as other studies like a study in Saudi Arabia 53% of our cases was under 20 months 0.44% of them between 20-80 months 3% over 10 years as same result of others study. Retroperitoan is dominant primary site (71%) like other studies. But there is not significant relation between metstatic bone marrow biopsy and survival. Our result about prognosis (30 month survival was 50%) is less than other countries.

Background: Acute Promyelocytic Leukemia (APL) is a well-defined subtype of Acute Myelocytic Leukemia (AML) and known by t (15;17) (PML-RARA) mutation. 20%-40% of AML patients indicate FMS-Like Tyrosine kinase 3 (FLT3) mutations. FLT3 mutations contain two famous mutations: FLT3-ITD (Internal Tandem Duplication) and FLT3-TKD (Tyrosine Kinase II Domain).

Objectives: Many studies have been done on FLT3-ITD. These studies have been acknowledged that the FLT3-ITD mutation had poor prognosis of on AML patients. This study was performed on two APL and APL+FLT3-ITD groups. This study aimed to compare differences in blood laboratory assays between APL and APL+FLT3-ITD patients.

Methods: This study contained 73 patients which divided in two groups: Acute promyelocytic leukemia and FLT3-ITD+acute promyelocytic leukemia. The study methods included: Cell counting and Peripheral Blood Smear (PBS), karyotype, extraction of mRNA and DNA, cDNA synthesis electrophoresis.

Results: This study was ruled out on patients involved with acute promyelocytic leukemia in GHAEM hospital Mashhad, Iran. All patients were diagnosed with t (15; 17) (PML-RARA). The age range of patients was 7-63 (mean: 30.86) and 58 (79.5%) (Male: 22, Female: 36) of patients were involved solely with APL and 15 (20.5%) (Male: 10, Female: 5) of them were APL+FLT3-ITD mutation. Blood parameters that were analyzed included: White Blood Cell (WBC), Red Blood Cell (RBC), Hemoglobin (Hb), Hematocrit (Hct), Mean Cell Volume (MCV) and Platelet (PLT) count. Each group of patients’ population was categorized into HIGH Risk factors and LOW Risk factors.

Conclusion: The consequence of current study demonstrated that FLT3-ITD mutation had a bad effect on laboratory assays in patients involved with Acute Promyelocytic Leukemia.

Over the past year many studies and clinical trials have been published in the osteoarthritis field. This research is based on how osteoarthritis develop by reporting the pathophysiology, prognosis, diagnosis and its treatments. We can cure osteoarthritis using the homoeopathic law "Similia Similibus Curanter," which aids in the treatment of the disease and by finding out the miasmatic approach.

Iron Deficiency Anemia (IDA) is one of the most common dietary deficiencies, accounting for about half of all instances of anemia. It is widespread in many impoverished nations. In most cases, thorough blood analysis and high serum ferritin levels may be used to diagnose this deficient disease. IDA may develop as a result of physiological pressures placed on developing children, adolescents, and pregnant women. In the case of all patients, however, the underlying reason should be explored. Inevitably, proper therapy of this illness improves quality of life, reduces iron deficient symptoms, and reduces the risk of death. The necessity of a blood transfusion oral iron supplementation and intravenous iron therapy are two therapeutic options. As a result, intravenous iron supplementation is regarded an undesirable technique, and the safety problems connected with this strategy in the event of extremely high dosages or in the context of very high ferritin levels are not well understood. The review's goal is to give a critical overview and up to date information about IDA diagnosis and treatment options.

The global pandemic of the Corona virus disease (COVID-19) has caused widespread morbidity and mortality globally. The complicated pathophysiology of COVID-19 and lack of a single therapy have made management a significant issue. Through comprehensive pharmacological, toxicological, and clinical research, AYUSH-64, a poly-herbal formulation developed by CCRAS, ministry of AYUSH, government of India, has demonstrated both its safety and effectiveness in treating infective febrile illnesses like malaria and influenza. Four components in AYUSH-64 include antiviral, immunomodulatory, anti-inflammatory, antipyretic, and anti-inflammatory properties. In COVID-19, it stops the inflammatory responses that lead to substantial morbidity. The government of India has also included AYUSH-64 in the National COVID management protocol based on Ayurveda and Yoga for asymptomatic and mild cases of COVID-19. The study summarizes the therapeutic potential of AYUSH-64 on the basis of clinical trials conducted in India on COVID-19.

Introduction: Soo ul qinya/pre dropsy is one of the liver diseases that also named as pre-dropsy. But, yet there is no precise method for diagnosis this disease. Therefore, this study aimed to develop “Soo Ul Qinya/Pre Dropsy” Diagnostic Tool (SUQDT) in traditional Persian medicine.

Materials and methods: A review study was conducted at 2018 on all 906 books and among credible texts of traditional Persian medicine that have been registered on noor islamic software was checked exactly. Moreover, "soo ul qinya" and "su ul qinya" and "pre dropsy" and "Sualaqani "Pish Istiqa" keywords was used for strategic searches in PubMed, Google Scholar, Scopus and Since Direct, web of sciences, SID and Irandoc. Finally, 15 reference books were chosen. The scoring of "soo ul qinya" signs conducted based on the number of repetition of each signs and symptoms and weighted by inverse-variance method.

Results: Of all traditional Persian medicine’s books, 15 title had detailed about "soo ul qinya" disease. Overall, 29 different signs have been pointed in three groups including absolute signs (pallor, edema of feet, hands, face, eyelids), probable but important signs (poor digestion, heavy feeling or fatigue) and probable but less important signs (perspiration decrease, increased appetite). Based on the number of repetitions and sign weight, the final score of each sign will be yielded and the SUQDT developed.

Conclusion: The "soo ul qinya" disease is not a well-defined but a diagnostic tool named SUQDT was developed based on different signs of disease and assessing the psychometric properties of it suggested.

Novel COVID-19 pandemic is shifting the outlook of the world on every materialistic thing. After each departing day, there are some points for optimism and agony both. Researchers are doing their best to slow down this contagious disease. Slowly the recovery rate is also boosting up. Now a new challenge is approaching up as post-recovery phase symptoms or follows up symptoms. Among the recovered individuals the mental symptoms like depression or stress are the most striking ones. The different modalities available for inner peace or reducing the depression, the meditation is most reliable and through different studies done on various parameters most evidence-based also. The practice of meditation in post recovered persons will not only bring inner solace reducing the physiological symptoms but will also reduce spending on health.