International Journal of Neurorehabilitation

Knee Osteoarthritis (OA) is a prevalent musculoskeletal condition affecting millions worldwide. Traditional treatments often focus on pain management and lifestyle adjustments. However, emerging research suggests that interventions targeting neurodynamics may offer promising therapeutic avenues. This feasibility study aims to assess the viability of incorporating active neurodynamics exercises into home-based management for patients with knee OA. Through a combination of literature review, theoretical framework exploration, and practical considerations, this study evaluates the potential benefits, challenges, and implications of such an intervention.

Peripheral Nerve Injuries (PNIs) represent a significant clinical challenge, often resulting in debilitating sensory, motor, and autonomic dysfunction. Traditional approaches to nerve repair have been limited in their ability to fully restore function, prompting the exploration of novel strategies within the realm of regenerative medicine. In this review, we delve into the latest advancements in peripheral nerve repair, focusing on innovative approaches that hold promise for revolutionizing the field. Before delving into novel approaches, it's crucial to grasp the intricate processes involved in nerve regeneration. Following injury, the peripheral nervous system exhibits a remarkable capacity for self-repair, orchestrated by a cascade of cellular and molecular events. Schwann cells, the principal glial cells of the peripheral nervous system, play a central role in promoting axonal regeneration through the secretion of growth factors and formation of regeneration-supportive microenvironments. However, the extent and efficacy of regeneration are often compromised by various factors, including the severity and type of injury.

Spinal Cord Injuries (SCI) often result in devastating and long-lasting consequences, impacting not only motor functions but also sensory and autonomic functions. Traditionally, the focus of rehabilitation has been on the spinal cord itself and its potential for recovery. However, emerging research suggests that the brain also plays a crucial role in the recovery process through mechanisms known as brain plasticity. This systematic review aims to comprehensively analyze existing literature on brain plasticity in patients with spinal cord injuries, exploring the underlying mechanisms, its implications for recovery, and potential therapeutic interventions. Through a meticulous search of databases and screening processes, relevant studies were identified and critically analyzed. The review sheds light on the multifaceted nature of brain plasticity in SCI patients, highlighting its potential as a target for innovative rehabilitation strategies and emphasizing the importance of interdisciplinary approaches in optimizing recovery outcomes.

Traumatic Brain Injury (TBI) remains a significant global health concern, with profound consequences for individuals and society. Despite advancements in medical technology and treatment strategies, the complex pathophysiology of TBI poses challenges for effective management. In recent years, novel perspectives have emerged, focusing on the identification of biomarkers and the exploration of exclusive medicinal targets. This essay explores these innovative approaches, highlighting their potential to revolutionize TBI diagnosis, prognosis, and treatment. Traumatic brain injury encompasses a broad spectrum of injuries resulting from external mechanical force, such as falls, accidents, or violence. The consequences of TBI can range from mild concussions to severe, life-altering impairments. Traditional diagnostic methods rely on clinical evaluation, neuroimaging, and cognitive assessments. However, these approaches may lack sensitivity and specificity, particularly in detecting subtle or delayed injury effects.