Journal of AIDS & Clinical Research

Nucleoside reverse transcriptase inhibitors (NRTIs) are cornerstone antiretroviral drugs used in the treatment of HIV/AIDS. The advent of novel NRTIs has expanded therapeutic options, offering improved efficacy and safety profiles. This article explores the pharmacokinetics and pharmacodynamics of these novel NRTIs, emphasizing their absorption, distribution, metabolism and excretion (ADME) properties, as well as their mechanisms of action, resistance profiles and clinical implications.

Implementing Pre-Exposure Prophylaxis (PrEP) programs presents both challenges and opportunities in public health. Challenges include access barriers, stigma, adherence issues and cost. However, effective implementation offers significant opportunities to reduce HIV transmission rates, improve health equity and empower at-risk populations through education and support. This abstract explores these dynamics, highlighting the critical factors influencing successful PrEP program implementation.

The advent of long-acting antiretroviral therapies (LA-ARTs) has revolutionized HIV/AIDS management by addressing adherence challenges associated with daily medication regimens. LA-ARTs offer sustained drug levels, reducing dosing frequency to weekly or monthly intervals. This review explores the clinical implications and applications of LA-ARTs in HIV/AIDS care, emphasizing their impact on treatment adherence, viral suppression and quality of life. Key studies demonstrate comparable efficacy to daily regimens with potential benefits in resource-limited settings and among marginalized populations. Challenges such as safety profiles, patient acceptance and healthcare infrastructure requirements are also discussed. As LA-ARTs continue to evolve, their integration into global HIV/AIDS treatment strategies holds promise for improving long-term outcomes and reducing transmission rates.