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Journal of Biomedical and Pharmaceutical Sciences

ISSN: 2952-8100

Open Access

Volume 3, Issue 4 (2020)

2021 Conference Announcement Pages: 1 - 1

7th World Congress - Exhibition on Antibiotics and Antibiotic Resistance

Bedeer Elsherbiny

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Awards 2021 Pages: 1 - 2

Awards for Pharamaceutical Chemistry

Niranjan Koirala

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Editor Note Pages: 1 - 1

Editorial note -Journal of Biomedical and Pharmaceutical Sciences

HUAJIA ZHANG

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Editor Note Pages: 1 - 1

Editorial notes- Journal of Biomedical and Pharmaceutical Sciences

Emmanuel Andres

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Research Pages: 1 - 4

The effect of Bryophyllum pinnatum (Lam) Oken (Crassulaceae) extract on enzymes involved in the inflammatory pathway

Onwubuya Emmanuel Ikechuckwu, Oladejo Afees Adebayo, Ogbunugafor Henrietta Aritetsoma, Okafor Chike Samuel, Ogbodo Chibuzor Uche

Bryophyllum pinnatum Lam.Oken (Crassulaceae) is widely used as food and as medicine in traditional medicine. The plant is found widely in tropical Africa, America, India and China. This study explores the bioactive compounds in the plant and investigates the effect of the hydro ethanol leaf extract on enzymes involved in the inflammatory pathways using GCMS and Cotton Pellet Induced Granuloma method. Results revealed that the hydro-ethanol leaf extract showed nine peaks, indicating nine bioactive compounds with 2-Amino-3-hydroxypyridine being highest (34.678%). Our findings indicated that the plant’s extract reduced inflammation in rats, causing a significant inhibition of inflammatory biomarkers (cyclooxygenases 1 and 2, interleukins 1β and 6 as well as prostaglandin E2) in a dose dependent manner. B. pinnatum leaf extract showed rich content of bioactive compounds which could be synthesized to produce new plant-based product to fight inflammatory disorders with fewer side effects.

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