Journal of Brain Research

Peripheral neuropathy (PN) is a common neurological condition characterized by pain, numbness or tingling, balance issues, mobility issues, and other symptoms brought on by injury or damage to the peripheral nervous system. The transmission of signals from the Central Nervous System to other parts of the body can be disrupted, distorted, or interrupted as a result of this damage, resulting in clinical symptoms. Muscle weakness, twitching under the skin, and muscle shrinkage are all signs of motor nerve damage. Tactile nerve harm can bring about agony and deadness. Damage to the autonomic nervous system can result in difficulty eating or swallowing, heat intolerance, or excessive sweating. There is a lack of consistent guidance for PN diagnosis and management due to the variety of symptoms and underlying causes.

An increasing number of studies are being conducted on brain implants with the intention of treating medical conditions that resist treatment or restoring physiological function. At the conclusion of such studies, management of the implanted device raises concerns. One choice is preceded with admittance to gadget usefulness and support for people who benefit from the intercession. What if, on the other hand, participants do not gain anything from an experimental brain implant? In most cases, there are two choices: leave the gadget embedded however idle or eliminate the gadget. In this study, we investigate the question of whether researchers studying brain implants are obligated to offer and pay for the device's removal.

The efferent (motor) and afferent (sensory) nerves may appear physically similar in structure, however with closer inspection, numerous differences could be observed in terms of cellular composition, extracellular matrix or structure. To investigate the reason for the differences, study was conducted on the gene expression of the afferent and efferent nerve fibers during the stage of growth and development. Analysis was conducted on the afferent and efferent nerve chip data of the mice (data coded GSE113820) from the GEO database. This set of data contained information derived from the nervous tissue of C57BL/6 mice. To reduce statistical bias, Weighted Gene Co-Expression Network Analysis (WGCNA) was used for the analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed in specific modules obtained after WGCNA analysis and the interaction network was constructed. It was found DEmRNAs in the PURPLE module were down regulated as the time of development progresses in the efferent nerves, in comparison there were only minor down regulation of the same DEmRNAs in the afferent nerves. These DEmRNAs were located in the postsynaptic membrane, cytoplasm and mitochondria, responsible for the function of anterograde transport of neurotransmitters and inhibition of apoptosis. The Kcna6 and Agpat4 were found to be the Hub gene of PURPLE module. These genes may play an important role during development in maintaining the function of sensory and motor nerves. WGCNA could be a useful tool that could help find different gene expressions in different types of nerves during development.

Insomnia is a common sleep disorder characterized by difficulty falling asleep, staying asleep, or both. Insomnia can be caused by a variety of factors, including stress, anxiety, depression, medications, and medical conditions. While insomnia is typically thought of as a sleep disorder, it can also have significant effects on neurological health. In this article, we will explore the relationship between insomnia and neurological disorders.

COVID-19 is a respiratory illness caused by the SARS-CoV-2 virus. The disease was first identified in Wuhan, China in December 2019 and has since spread globally. COVID-19 primarily spreads through respiratory droplets when an infected person coughs or sneezes. Symptoms of COVID-19 can range from mild to severe, with some patients requiring hospitalization. The most common symptoms of COVID-19 include fever, cough, and shortness of breath, but it is now understood that neurological symptoms can also occur.