Biosensors & Bioelectronics

This study introduces a novel approach utilizing flexible alginate hydrogels as a platform for on-tissue writable bioelectronics. Alginate hydrogels possess several advantageous properties, such as biocompatibility, mechanical flexibility, and the ability to conduct and adhere to various tissue surfaces. Leveraging these characteristics, we developed a conductive and adhesive granular alginate hydrogel system that allows seamless integration with biological tissues. The granular alginate hydrogels were engineered by incorporating conductive nanoparticles into the alginate matrix, enabling electrical conductivity while maintaining the hydrogel's flexibility. The adhesive properties were achieved through the introduction of specific functional groups that promote strong adhesion to tissue surfaces. This unique combination of conductivity and adhesion facilitates the creation of on-tissue writable bioelectronics, enabling precise and localized electrical stimulation or sensing. To demonstrate the versatility and potential applications of our flexible alginate hydrogel system, we successfully fabricated on-tissue writable electrodes and sensors. These devices exhibited excellent conformability, conforming to the irregular contours of various tissues, such as skin, organs, and neural tissues. The granular alginate hydrogel enabled direct writing and patterning of conductive tracks on tissue surfaces, providing a simple and customizable approach for bioelectronic circuitry design.

The development of innovative and efficient analytical techniques for dairy analysis is of utmost importance in ensuring food safety and quality. In this study, we present a novel approach to enhance dairy analysis through the utilization of a bioelectronic tongue modified with Gold Nanoparticles (AuNPs).The bioelectronic tongue is a sensing platform designed to mimic the human taste sensation by integrating various sensing elements. By incorporating AuNPs onto the surface of the bioelectronic tongue, we aim to improve its analytical capabilities specifically for dairy products. Gold nanoparticles have unique physicochemical properties, including a high surface area-to-volume ratio, excellent electrical conductivity, and biocompatibility, making them ideal candidates for enhancing sensing platforms.

We demonstrate the successful modification of the bioelectronic tongue with AuNPs using a simple and efficient immobilization method. The presence of the AuNPs significantly enhances the sensitivity and selectivity of the bioelectronic tongue towards key dairy components such as proteins, fats, sugars, and flavour compounds. Through extensive experimentation and validation, we illustrate the superior performance of the AuNP-modified bioelectronic tongue in detecting and quantifying various dairy analytes. The platform exhibits excellent accuracy, reproducibility, and stability, making it a promising tool for routine dairy analysis in laboratories and quality control settings. Furthermore, we investigate the mechanism behind the improved sensing capabilities of the AuNP-modified bioelectronic tongue, shedding light on the interactions between the gold nanoparticles and the target analytes.

High-Performance Flexible Sensors for Real-Time Health Monitoring have emerged as a disruptive technology in the field of healthcare. These sensors offer a unique combination of flexibility, sensitivity, and real-time data acquisition, enabling continuous and accurate monitoring of vital health parameters. By seamlessly integrating with the human body, these sensors provide a non-invasive and unobtrusive approach to health monitoring. They can measure a wide range of physiological signals, including heart rate, blood pressure, body temperature, respiratory rate, and muscle activity, among others. The real-time data collected by these sensors can be wirelessly transmitted, allowing for remote monitoring and timely interventions if required. With their ability to provide continuous monitoring, adapt to body contours, and offer comfort and convenience, high-performance flexible sensors have the potential to revolutionize healthcare by improving early detection, diagnosis, and management of various health conditions.

Bacterial membrane analogues have emerged as a promising field of research, offering new opportunities for the development of biosensing and therapeutic strategies. The bacterial membrane plays a vital role in various biological processes, including nutrient transport, cell signaling, and defense mechanisms. By mimicking the structure and function of these membranes, scientists can harness their unique properties for diverse applications. In the realm of biosensing, bacterial membrane analogues enable the creation of highly sensitive and selective biosensors for the detection of pathogens and other target molecules. These biosensors have the potential to revolutionize disease diagnostics, environmental monitoring, and food safety assessment.

By replicating the components and properties of bacterial membranes, researchers can design synthetic membranes that interfere with bacterial adhesion, colonization, and biofilm formation. This opens up avenues for the development of novel antimicrobial approaches to combat drugresistant bacteria. Furthermore, the incorporation of therapeutic agents into bacterial membrane analogues allows for targeted drug delivery systems, enabling precise and controlled release of medications. This has the potential to enhance treatment efficacy while minimizing side effects. In summary, bacterial membrane analogues hold great promise in advancing biosensing technologies and therapeutic strategies. Continued research in this field is essential for unlocking their full potential in addressing the challenges of infectious diseases and improving healthcare outcomes.