Cardiovascular Diseases & Diagnosis

Mobile phone battery blast injury was a rare thing in the past, however with technological advancement it’s on the rise. It usually involves the hand, face, eyes though can involves others too. The manifestation of hand injuries due to cellphone battery explosion commonly occurs with thenar muscle injury, 1^st web split, dislocation of CMC joint of thumb and amputations of other digits.

The considerable underlying structural abnormalities are not taken into account by the description of atrial fibrillation (AF) as a functional electrical condition. Microstructural alteration of the muscular sleeve of the atrium and pulmonary vein (PV) creates a weak foundation for the maintenance of AF. Despite a lack of knowledge about the anatomical and functional underpinnings of AF, current data show that this arrhythmia typically needs a trigger for start and a weak electrophysiological and/or anatomical substrate for maintenance. It is currently unknown if the trigger mechanisms involve micro re-entry from cardiac tissue, prompted activity, or focused improved automaticity. Both sympathetic and parasympathetic stimuli, which also appear to be involved in AF maintenance, can promote AF onset. Inflammation is linked to both new-onset and recurrent AF through a mechanism that may involve cellular ageing, apoptosis, and ensuing atrial fibrosis, according to growing clinical data.

Chronic heart failure (CHF), which affects a large portion of the global population on a regular basis, frequently progresses to a life-threatening disease, and has a high mortality rate, is another significant global public health issue. We want to find out what progress has been made recently in the care of CHF patients whose left ventricular ejection fraction (LVEF) is below 40%. BNP has been implicated in the aetiology of cardiac disease in recent years. For this reason, we attempted to study the outcomes of the sophisticated medical therapy strategy applied to CHF patients using the combination of sacubitril/alsartan, an angiotensin receptor neprilysin inhibitor. Additionally, we looked into the device therapeutic approaches applied to these patients' care, specifically cardiac resynchronization therapy. Finally, we compared the outcomes of cardiac resynchronization therapy to those of a sophisticated medical treatment strategy using the combination of sacubitril/valsartan, an angiotensin receptor neprilysin inhibitor.