Journal of Clinical Research

Pallister-Killian Syndrome is a rare genetic disease caused by mosaicism for tetrasomy of chromosome 12. It is characterized by dysmorphic phenotype and multiple organs malformation. This syndrome also includes developmental disabilities such as intellectual and motor disability, muscle hypotonia and it is often related with seizures. Here below we present the case of a patient diagnosed in early neonatal period, highlighting the importance of clinical findings which define this syndromet.

This study explores the effect of the financial crisis on the consumer and its impact on psychological well-being and life satisfaction with the core question investigating what effect the financial crisis has on the psychological well-being and life satisfaction of house hold heads in the United Kingdom. The reversed model approach used in the study analysed from two perspectives before and after the financial crisis. One is to investigate the psychological well-being using the general health questionnaire and its effect on health, life satisfaction and financial incapability. The second is to investigate financial incapability and its effect on health, life satisfaction and psychological well-being based on the British Household Panel (1991-2009) and Understanding Society (2010) Surveys.

They are two integrated large nationwide panel surveys commissioned by the United Kingdom government as an instrument to measure social and economic indicators at the individual and household level. The result of the analysis indicates that overall life satisfaction and financial incapability are important determinants of psychological well-being. The paper further explores the impact of the financial crisis on a household head before and after the crash. The results suggest that satisfaction with life, health implications, psychological well-being, and financial capability were significantly lower after the financial crisis. In conclusion, the results explain why overall life satisfaction generally affects individuals’ psychological wellbeing and financial capability, and why those with high financial incapability have poor psychological well-being.

Introduction: Fifth metacarpal neck fracture is the most common fracture of the hand. It is often related to aggressive, intentional punching Due to intrinsic muscle pull, the metacarpal head angulates volarly. Some of the most common causes of hand injuries are crush/compression injuries, blunt trauma, fall, road traffic accidents, machinery injury, sports related activity, explosions and firearm injuries. A variety of methods and algorithms are available to treat the metacarpal fractures. In our study we have aimed to compare the different modalities of treatment of boxer’s fracture in the form of conservative treatment, k-wire and JESS fixator.

Materials and methods: This was a prospective study conducted from January 2021 to June 2021. 45 subjects were included in one study and divided into three groups randomly for the different treatment modalities in the form of K wire, JESS fixator and closed reduction with POP slab for boxer’s fracture. Follow up was assessed using DASH score.

Results: Only 26.6% of the patients in group A as compared to 60% in group B had excellent results. 46.6% of the patients in group C had excellent results. The study revealed a poor outcome in 26.6% of group A, 13.3% of group B and 20% of group C patients.

Conclusion: From the results, we could conclude that JESS fixator was more effective than other two modalities in the treatment of boxer’s fracture with the emphasis to be provided on regular pin tract dressing.

Introduction: Sites where clinical trial will be conducted is the main place in centralized trials in generation data by the patients. Sites without patients lead to absence of clinical trial data and failed of clinical trial. Feasibility stage in selection of sites for conducting of particular clinical trial is emphasis to presence of needed pool of patients. Recruitment of patients in centralized trials is announcing by PI of clinical sites during the feasibility stage. This is subjective decision of investigator based on integral approach like experience, incidence of disease and many other parameters. The objective approach like calculation is apparently needed for calculation of proposed recruitment on the stage of feasibility.

Materials and methods: Retrospective analysis data of four clinical trials II-III phases, conducted since 2007 to 2017 years.

Aim: To find out the approach for selecting the trial sites on predictive basis using objective methods on the on the stage of feasibility.

Statistical analysis: Data had been collected from feasibility questionnaires, open statistical sources.

Results: It was proposed the formula for evaluation of clinical trial site in perspective of recruitment.

Discussion: Selection of sites might be calculated which will decrease the number of failed clinical trials. We called the calculation “Calculated Proposed Patient’s Recruitment”-CPPR».

Management of patients with Deep Vein Thrombosis (DVT) in the Emergency Department (ED) has dramatically changed over the last 10 years in the absence of a shared management, leading to the need of a shared consensus strategy to standardize the diagnostic and therapeutic approach in acute phase of DVT in a setting where standardization is particularly difficult due to the volume of activity and the number of operators who alternate in the care of the individual patient. We perform a review and comment of a NGT work performed by a panel of 5 Italian experts who developed 21 consensus statements based on available evidence and their clinical experience. Considering the best available evidence and the longstanding clinical experience of 5 Italian EDs’ experts, the management of patients with suspected DVT to ED should be characterized by a standardized diagnostic process, guided by the estimation of pre-test clinical probability with formal and validated Clinical Prediction Rule (CPR), an increase in the number of patients discharged directly from the ED, reserving hospitalization only for high-risk patients and faster and more appropriate use of the wide range of anticoagulant drugs currently available. In conclusion such a guide will standardize the diagnostic and therapeutic approach in acute phase of DVT, limit the number of diagnostic tests performed to exclude or confirm DVT and shorten the stay time of these patients in ED without reducing safety. Indeed, the identification of simple criteria for the definition of high-risk DVT together with availability of DOACs will allow physicians to safely discharge all DVT patients who do not meet these risk criteria, directly from the emergency room.