Journal of Cosmetology & Trichology

Background: Hair loss is a debilitating condition often encountered by older adults. Common hair loss treatments such as Minoxidil and Finasteride are associated with potentially severe adverse effects. Ageratum conyzoides L., an annual herb shown to inhibit pathways associated with hair-loss is a potential safe and effective alternative treatment for hair loss. Objective: A pilot, open-label, randomized, parallel and in vitro study assessed the efficacy and safety of an Ageratum conyzoides formulation on hair loss. Methods: 28 otherwise healthy males and females over 18 years of age exhibiting pattern baldness received either a 0.5% or 1% strength A. conyzoides gel formulation to be applied topically twice per day for 8 weeks. Hair growth as measured by temporal recession distance and participants' quality of life was assessed by the Hair Distress Questionnaire. The effect of an A. conyzoides extract on gene expression of 5α-reductase and release of prostaglandin D2 (PGD2) in human Hair Dermal Papilla Cells (HHDPC) was also assessed to determine mechanisms of action. Results: Temporal recession in men reduced from 9.1 cm to 8.6 cm in the 1% group and from 8.6 to 7.5 cm in the 0.5% group. The normal distance in men without recession is between 6-6.5 cm. Among males, hair distress questionnaire scores fell by 6 and 3.6 points from baseline for the 0.5% and 1% product respectively. In the 1% treatment group, 64% of men and 100% of women reported an improvement in their hair loss symptoms. Over 65% of participants indicated a significant improvement in their hair related quality of life (p<0.05). In the in vitro study, the A. conyzoides extract significantly inhibited PGD2 release and 5 α-reductase type 1 expression in HHDPC. Conclusion: These results indicate that A. conyzoides may be an effective treatment option for facilitating hair growth and inhibiting hair loss. Abbreviations: AGA, Androgenetic Alopecia; PGDS, Prostaglandin D synthase; PGD2, Prostaglandin D2; HHDPC, Human Hair Dermal Papilla Cells; DHT, Dihydrotestosterone.

We gratefully thank all our wonderful Speakers, Conference Attendees, Students, Media Partners, Associations and Exhibitors for making “28th Euro Dentistry Congress” Conference the best ever held during September 16-17, 2019 at Park Plaza Amsterdam Airport Hotel | Amsterdam, Netherlands with a theme “Discovering New Exploration in Dental & Oral Health” The conference received salutations & immense support was extended by the keynote lectures mentioned below: Adel Abdel Azeem El Bardissy, Cairo University, Egypt

Beauty Lies Not Only in the Eyes of Beholder but also in the Hands of Cosmetologist and Dermatologist. Cosmetology Meetings gladly announces the commencement of the most grandeur event where the world’s most talented beauty doctors, i.e., Cosmetologists & Dermatologists meet and showcase their talent and experience over years in the biggest meet of the annual 2021 – “16th International Conference on Cosmetic Dermatology and Aesthetic Medicine” to be held on June 22-23, 2021 Paris, France, with the theme: “Recent advancements in skin treatment and aesthetic medicine

Cosmetology is the research and execution of skills to beautify the eyes, face and hair and Dermatology is the medical division that deals with the skin. For both medical and surgical elements, it is a speciality. It is a combination in both medical and surgical elements. Dermatology treatments strengthen the skin's natural appearance by addressing different disorders, such as hyperpigmentation, acne, scars, and wrinkles. Liposuction is exclusively for doctors. Cosmetic dermatology helps to evaluate and cure cosmetic skin disorders with treatments such as Botox, injections of collagen, chemical peels, dermabrasion, laser treatment and liposuction.

CXXC5 negatively regulates the Wnt signaling pathway by binding to the Wnt signaling component protein disheveled (Dvl). The Dvl protein comprises three domains: the DIX domain, the DEP domain, and the PDZ domain. The PDZ domain binds to the CXXC5 zinc finger domain. We prevented the CXXC5 effect by using a DNA aptamer (WD-Aptamer) that binds to the Dvl1_PDZ domain. The inhibitory effect of CXXC5 was confirmed through tests of cell proliferation in HaCaT cells and in vivo experiments using mice.