Journal of Genetics and Genomes

Mutation detection is a crucial aspect of genetic research, enabling us to understand the mechanisms underlying genetic disorders and evolutionary processes. However, detecting spontaneous mutations in DNA, particularly in the case of E. coli, poses significant challenges due to background noise. In this article, we explore the application of duplex DNA sequencing as a powerful tool to overcome these limitations and enhance mutation detection in E. coli DNA. By utilizing this innovative technique, researchers can gain deeper insights into the mutational landscape of E. coli, leading to a better understanding of its adaptive responses, genetic stability and potential implications in various fields of biology and medicine.

Complex psychiatric disorders pose significant challenges in diagnosis and treatment due to their multifactorial nature and inherent heterogeneity. However, the emergence of Artificial Intelligence (AI)-associated computational tools offers new possibilities for advancing our understanding of these disorders and improving patient care. This article explores the potential of AI-based computational tools in detecting and enhancing the treatment of complex psychiatric disorders, with a specific focus on Major Depressive Disorder. By leveraging integrative analysis techniques, such as bioinformatics and machine learning, on transcriptomics data, promising MDD-related biomarkers and pathways have been identified, paving the way for personalized medicine and targeted interventions.