Journal of Hypertension: Open Access

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a rare but potentially life-threatening complication of acute pulmonary embolism, characterized by persistent pulmonary hypertension due to organized thromboembolic obstruction of the pulmonary arteries. While CTEPH shares similarities with other forms of pulmonary hypertension, it presents unique challenges in terms of diagnosis, treatment and prognosis. This review provides an overview of the comorbidities associated with CTEPH, current treatment options and factors influencing survival in patients with this condition. Understanding the complex interplay between comorbidities, treatment strategies and survival outcomes is essential for optimizing the management of CTEPH and improving patient outcomes.

Portal hypertension is a common complication of cirrhosis, contributing to significant morbidity and mortality in patients with chronic liver disease. Non-invasive methods for diagnosing portal hypertension have emerged as valuable tools for risk stratification, treatment monitoring and prognostication in patients with Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV)-related cirrhosis. This review provides a comprehensive overview of non-invasive methods for portal hypertension diagnosis, including imaging techniques, serum biomarkers and transient elastography. The utility, accuracy and limitations of non-invasive diagnostic modalities in HBV-and HCV-related cirrhosis are discussed, with a focus on their clinical implications and future directions in liver disease management.

Gene therapy has emerged as a promising approach for addressing cardiovascular diseases such as hypertension, atherosclerosis and Familial Hypercholesterolemia (FH). This review explores the evolution of gene therapy techniques and their applications in the management of these cardiovascular conditions. We discuss the underlying molecular mechanisms, delivery methods and therapeutic targets utilized in gene therapy interventions for hypertension, atherosclerosis and FH. Furthermore, we highlight recent advancements, challenges and future directions in the field of cardiovascular gene therapy, with the potential to revolutionize the treatment of these prevalent and debilitating conditions.

This study investigates the acute effects of exercise on systemic capillary responses in hypertensive elderly individuals. Hypertension presents a significant risk factor for cardiovascular disease and understanding the vascular responses to exercise in this population is crucial for developing effective interventions. Twenty hypertensive elderly participants engaged in a single bout of moderate-intensity exercise and systemic capillary responses were assessed before and after exercise using non-invasive techniques. Results revealed dynamic changes in systemic capillary function following acute exercise, suggesting potential benefits for vascular health in hypertensive elderly individuals.