Journal of Integrative Oncology

Three decades of basic research have largely elucidated the oncogenic mechanisms of human papilloma virus (HPV). HPV protein E5 achieves a takedown of antigen presentation to evade immune evasion while also impairing the ubiquitin turnover of EGFR. HPV E6 and E7 causes turnover of key tumor suppressor genes, p53 and PTPN13, and Rb1 and PTPN14, respectively. The signaling pathway consequences and resulting transcriptional reorganization that results in malignant behavior is discussed regarding the complex, self-perpetuating network of HPV. The potential utility of network-targeting combination therapy by re-purposing rimantidine, withaferin A, and curcumin to rescue the tumor suppressor proteins and re-establish immune recognition is discussed as a strategy to achieve deactivation of the malignant network that leads to collapse of the disease and reversal of therapeutic resistance. Investigation of this re-purposing regimen to block hypoxia by achieving cell cycle arrest could permit the use of lower doses of radiation that have potential to enhance treatment efficacy and survival while also decreasing the long-term side effects of radiotherapy.

Objective: Breast cancer is the most common type of cancer and the second leading cause of cancer death among women. Early detection of breast cancer leads to almost complete cure. Breast cancer screening includes breast self-examination, clinical breast examination, and mammography.

Methods: This is an interventional (descriptive) study. The study population was 400 female employees working for 20 years-45 years under the auspices of Shushtar health centers. Which were randomly divided into two groups of intervention (n=100) and control (n=100). The educational intervention was performed in two sessions of 60 minutes. Data were collected by completing a questionnaire as well as a performance checklist during a direct interview before the educational intervention and two months after. After co-ordination with all health centers in Shushtar city and making available the population of women working staff aged 20 years-45 years, sampling was performed in two stages. In order to analyze the data using SPSS software. Ver 25. To describe the data, frequency, percentage, mean and standard deviation, ANOVA and paired analysis test will be used.

Results: 400 women working in comprehensive health centers in Shushtar city were investigated in this study. Most of the surveyed working women were 35 years-40 years old (32/5) 130. The highest rate of marital status of working women is married (60) 240. Likewise, the results showed that the education level of most working women (45) was 180 of the participants in the bachelor study. The results of the ttest showed that there was a significant difference between all the components of breast self-examination before and after the intervention. The results of the paired t-test showed that there was a significant difference between all the components of breast self-examination before and after the intervention.

Conclusion: BASNEF model was effective in breast self-examination training in women aged 20 years-45 years in Shushtar comprehensive health centers and increased the scores of knowledge, attitude, abstract norms, enabling factors and performance.