Medical Microbiology & Diagnosis

Postbiotics, products, or metabolites secreted by living probiotic bacteria like thioic acids, peptides, enzymes, peptidoglycan taken peptidoglycans, polysaccharides, organic acids and cell external proteins, are said at be produced during the bacterial fermentation process. Postbiotics may provide immunization, anti-oxidant, Prevents inflammation, low cholesterolemic, antimicrobial, antagonistic obesity, contrast hypertensive and diabetic retinopathy, impacts. This work attempted to show the antimicrobial performance of postbiotics. In this regard, we consider microbial strains used as postbiotic sources and also postbiotics as antimicrobial agents in food products. Studies show that as probiotics are fed special forms of fiber (prebiotic) molecules, indicate substances known as postbiotics. Short chain fatty acids like acetate, propionate, and butyrate are among in between broadly studied postbiotics. The process of extraction and purification of postbiotics is performed by centrifugation, dialysis, and freeze-drying. These features show that postbiotics assist to increase host health by increasing certain physiological functions. On the other hand, postbiotics can be used to increment the Useful lifetime various Foodstuffs, including dairy products. Research has shown that the addition of postbiotic powder resulting from freeze-drying of these products can prevent mold spoilage. This is due to the antimicrobial effects of postbiotic compounds. It is said that in the near future we will see significant advances in the biological preservation of food.

Objective: We present a postnatal diagnosis of 17q12 micro-duplication with no obvious phenotypic abnormality

Case review: A female newborn weighing 2058 g was delivered NVD at 34+5 weeks of gestation to a Gravida 3 Para 2 23 year old mother, who had an antenatal history of significant maternal polyhydraminos. The baby was born flat and cyanosed with an APGAR score of 3.

Discussion: The chromosomal microarray analysis revealed a copy number gain (4 copies) of “unknown significance” of the long arm of chromosome 17 at 17q12 of size 431 kbp and encompassing 7 OMIM genes. The result also showed stretches of LOH (loss of hetrozygosity) on several chromosomes. The mitochondrial genome analysis identified a heterozygous likely pathogenic variant in the ANKRD11 gene. This result is consistent with the genetic diagnosis of autosomal dominant KBG syndrome. Physical examination revealed edema and ascites. The baby had no major dysmorphic features.

Conclusion: The 17q12 microduplication can demonstrate distinctive phenotypes, including no abnormal presentation. Nevertheless, the patient should be monitored and assessed through childhood and adulthood for any neuropsychiatric problems.