Journal of Oncology Translational Research

Gastric cancer is one of the most common and deadly cancers worldwide, particularly in East Asia. It has a complex etiology involving genetic, environmental, and lifestyle factors. Among the molecular alterations associated with gastric cancer, the overexpression of certain genes plays a crucial role in tumorigenesis and progression. One such gene that has gained attention is Mitotic Spindle Positioning (MISP). MISP is involved in cell division and mitotic spindle positioning, which are critical for maintaining genomic stability. Recent studies have indicated that MISP overexpression may be linked to gastric cancer and its precursor lesion, intestinal metaplasia. This essay explores the role of MISP in gastric cancer and intestinal metaplasia, discussing its biological function, the evidence supporting its overexpression in these conditions, and the potential implications for diagnosis and treatment.

Angiogenesis, the formation of new blood vessels, plays a crucial role in tumor growth and metastasis. Antiangiogenic therapy has emerged as a promising strategy to impede tumor progression by targeting tumor vasculature. While traditional antiangiogenic agents have shown efficacy in certain cancers, their limitations, such as drug resistance and adverse effects, highlight the need for novel approaches. This article explores recent advancements in targeting tumor vasculature, including innovative therapeutic modalities and combination strategies, aiming to enhance treatment outcomes and overcome existing challenges in antiangiogenic therapy.

Cancer diagnosis has long relied on tissue biopsies for accurate identification and characterization of tumors. These biopsies serve as the cornerstone of cancer diagnosis, guiding treatment decisions and providing vital information about the nature and behavior of the disease. However, traditional biopsy techniques are not without limitations, often presenting challenges in obtaining adequate tissue samples and accurately assessing tumor characteristics. In recent years, precision biopsy techniques have emerged as a promising approach to overcome these challenges, offering improved diagnostic accuracy and enhancing personalized cancer care. In this article, we explore the significance of precision biopsy techniques in the realm of cancer diagnosis and their potential to revolutionize the way we detect and manage cancer.

Ascorbic acid, commonly known as vitamin C, has long been recognized for its essential role in human health, particularly in preventing scurvy and boosting the immune system. Over the past few decades, there has been increasing interest in the potential use of ascorbic acid in the treatment of cancer. This interest is driven by both anecdotal reports and scientific research suggesting that high doses of vitamin C may have therapeutic effects against cancer. This paper explores the historical context, mechanisms of action, clinical studies, and current status of ascorbic acid in cancer treatment.