Journal of Vasculitis

A case of large vessel vasculitis as a paraneoplastic syndrome of endometrial cancer is presented which is the first documented case in the literature. Presenting initially as undifferentiated abdominal pain, routine tests presented no clear diagnosis beyond aortitis. PET scan and biopsy showed a non-Mullerian origin endometrial cancer, with the aortitis a likely paraneoplastic syndrome. This syndrome has been demonstrated in other cancers such as myelodysplastic syndromes albeit rarely, but this case opens up differential diagnoses for unexplained large vessel vasculitis cases.

Mesenteries are double layers of peritoneum in the abdominal cavity and are continuations of the visceral and parietal peritoneum with the serous membranes adhered back to back so that the outer mesothelium secretes serous fluid into the peritoneal cavity. This decreases the friction between the adjacent visceral surfaces and allows some movement of the organs that occur during digestion. The mesentery attaches the intestines to the abdominal wall, and also helps storing the fat and allows the blood and lymph vessels, as well as the nerves, to supply the intestines.

Lupus is a long-term autoimmune disease in which the body's immune system becomes hyperactive and attacks normal, healthy tissue. Symptoms include inflammation, swelling, and damage to the joints, skin, kidneys, blood, heart, and lungs. Lupus is a disease that predominantly affects women, often striking at the prime of life,” Somers says. “Through the MILES Program, we previously showed that for black women, who are disproportionately affected by lupus, their risk of lupus is highest in their Twentys.40% of black females with lupus have kidney involvement, and 15% have end-stage renal disease”.

Purpura is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. They measure 3–10 mm, whereas petechiae measure less than 3 mm, and ecchymoses greater than 1 cm. Purpura is common with typhus and can be present with meningitis caused by meningococci or septicaemia. In particular, meningococcus (Neisseria meningitidis), a Gram-negative diplococcus organism, releases endotoxin when it lyses. Endotoxin activates the Hageman factor, which causes disseminated intravascular coagulation. The DIC is what appears as a rash on the affected individual.

Arthritis is the swelling and tenderness of one or more of your joints. The main symptoms of arthritis are joint pain and stiffness, which typically worsen with age. The most common types of arthritis are osteoarthritis and rheumatoid arthritis. Arthritis is an inflammation of the joints. It can affect one joint or multiple joints. There are more than 100 different types of arthritis, with different causes and treatment methods. Two of the most common types are osteoarthritis and rheumatoid arthritis.

Infarction is tissue death necrosis due to inadequate blood supply to the affected area. It may be caused by artery blockages, rupture, mechanical compression, or vasoconstriction. The resulting lesion is referred to as an infarct from the Latin infarctus, "stuffed into". Infarction, death of tissue resulting from a failure of blood supply, commonly due to obstruction of a blood vessel by a blood clot or narrowing of the blood-vessel channel. The dead tissue is called an infarct. Myocardial infarction heart attack death of a section of heart muscle results from obstruction of a coronary artery; the condition often accompanies coronary thrombosis. Infarctions may also occur in the lungs pulmonary infarction and the brain see stroke.