Journal of Dermatology and Dermatologic Diseases

Giant congenital melanocytic nevi a ≥ 20 cm is rare in adolescents and adults. Here we present a case of subcutaneous melanoma developing in congenital giant naevus with complete regression of superficial dermoepidermal part. A 17 yr old girl presented with a painless and gradually increasing swelling in her right temporal region on pre-existing giant congenital menocytic naevus (GCMN) on right hemiface. FNAC proved the case as malignant melanoma of temporal region with metastatic deposit in cervical lymph node. On histopathological examination it was found that the melanoma arising deep in the subcutaneous tissue with extensive involvement of deeper structures, extensive metastasis of cervical lymph nodes, salivary glands, deeper soft tissues with spontaneous regression of superficial epidermal and dermal part. Though regression is seen in melanomas, spontaneous regression has been mostly seen in melanomas with only intraepidermal component.

Background: The liver and kidneys play apivotal role in the metabolism of nutrients, drugs, hormones, metabolic waste products and thereby maintaining body homeostasis. The present study was planned to demonstrate the favorable hepatonephroprotective effect of honey or propolis against CCl4 histopathological, histochemical and immunohistochemistry.

Material and methods: Rats were randomly divided into 4 groups: The first group of 10 rats serves as control. The second were maintained as CCl4, then third and fourth maintained as honey and propolis respectively for period of experiment (6 weeks). Pieces of liver and kidney were subjected to histopathological and immunohistochemistry procdures and the obtained sections (5 μm thick) were stained with H&E also with silver nitrate stain and anti laminin antibody for immuno- histochemistry.

Result: Marked histopathological alteration were observed in the studied sections under the influence of CCl4, the most common changes were cloudy swelling of hepatocytes, fatty changes, clear vacuolation of renal cells and congested blood vessels. After treated with honey and propolis showed improvement of hepatocytes and renal tissues.

Conclusion: This study indicated that CCl4 has a toxic effect on liver and kidney. Honey and propolis improve the structural integrity of the cell membrane and ameliorates histopathological, histochemical and immunohistochemistry changes.

Medications may induce a variety of different forms of mucocutaneous pigmentation, including melanosis. This short review discusses about various drugs implicated in oral mucosal pigmentation and also pigmentation caused by heavy metal ingestion.

Nevus of Ota is a dermal melanocytic hamartoma of unknown cause and rare in Indian subcontinent, associated with ophthalmic, maxillary and mandibular divisions of trigeminal nerve. Oral involvement of nevus of ota is very rare and found mostly in females. This review highlights this obscure, but important oro-facial pigmentation.

Cancer of the skin, in general, is believed to be rather uncommon in black persons. Collected reports from the US showed that, out of 357 skin cancer cases, 5 (1.4%) were expressly stated to be albinos. A Nigerian comparable series of 435 patients manifested 15 (3.4%) albinos. Therefore, it is hypothesized that albinism is a good model for studies on skin adaptation as it concerns albinos in USA and in an indigenous people of Nigeria and elsewhere.

Neurofibromatosis type 1 is a relatively common inherited disease. The condition may involve frequently difficult to manage benign and malignant tumors in affected patients and can also affect tissues such as bone and skin. Symptoms include large numbers of cafe-au-lait macules, tumoral lesions known as neurofibromas, and scoliosis in the spinal cord. Tumors may also be seen in the brain, the cranial nerves or the spinal cord. This study discusses type 1 neurofibromatosis in the light of the current literature.