Journal of Dermatology and Dermatologic Diseases

Inflammatory linear verrucous epidermal nevus is a rare variant of nevoid linear inflammatory dermatoses which appear most often in first six months of life and persists for many years or even whole life. Clinically it often shares many features with linear psoriasis, linear porokeratosis and other linear dermatoses which can usually be differentiated by an established set of clinical and histopathological criteria. Herein we are reporting an interesting and rare case fulfilling all the clinical and histopathological criteria of inflammatory linear verrucous epidermal nevus in a 13 year old boy which uniquely revealed cornoid lamella on histopathology so we termed it as “porokeratotic variant of inflammatory linear verrucous epidermal nevus”. To the best of our knowledge, only two such cases were reported previously in the literature and none from our country.

Combined dyspigmentation such as lentigines intermingled with freckles, or melasma with acquired bilateral nevus of Ota-like macules, are common among women in Taiwan. There are various lasers available, including Qswitched Nd-YAG laser, Q-switched alexandrite laser, Q-switched ruby laser, and pico laser. We conducted a literature review to understand the current practice of treatment for pigmented lesions in Taiwan.

Our purpose is to study the efficacy of the alexandrite laser (755 nm) and the fractional laser when treating pigmentary lesions .We use the data of our private office of the last five years (2011-2015) We treated 1000 patients with freckles with alexandrite laser, 200 patients with melasma with fractional laser, 100 patients with post inflammatory hyperpigmentation with alexandrite laser and 60 patients with post inflammatory hyperpigmentation with fractional laser. We also studied the side effects of the therapies. Alexandrite laser has excellent results for freckles, while the combination of chemical peelings and fractional laser is good for the treatment of melasma. Post inflammatory hyperpigmentation has an intermediate response. The recurrence rates are higher in melasma and the side effects are generally minimal.

52 year old obese postmenopausal female presented with complaints of multiple painful lumps over the legs and thighs of 2 years days duration. Clinical examination revealed multiple tender plaques and nodules over both the legs and thighs of different sizes. Biopsy suggestive of lipoma. These features were diagnostic of a rare lipomatosis, dercum’s disease.

Vitiligo may be a future skin condition characterized by patches of the skin losing their pigment. The patches of skin affected become white and frequently have sharp margins. The hair from the skin may additionally become white. Within the mouth and nose may additionally be concerned. Generally, each side of the body area unit affected. Typically the patches begin on area units of skin that are exposed to the sun. It’s a lot of noticeable in folks with dark skin. Skin problem could end in psychological stress and people affected could also be stigmatized. The cause is often unknown. It’s believed to ensure to genetic susceptibleness that's triggered by associate degree environmental issue specified associate degree autoimmune disorder happens. This leads to the destruction of skin pigment cells. Risk factors embrace a case history of the condition or different response diseases, like a glandular disease, alopecia, and malignant anemia. Skin problem is assessed into 2 main types: segmental and non-segmental. Most cases area unit non-segmental which means they have an effect on each side and generally degenerate with time. Concerning 100 percent of cases area unit segmental which means they principally involve one facet of the body and don't generally worsen with time. Diagnosing may be confirmed by tissue diagnostic test.

Porokeratosis is an inherited, clonal disorder of epidermal keratinization classically characterized by development of single or multiple annular lesions with raised, sharply marginated, keratotic ridge and central atrophy. This clinical presentation may vary with different types of porokeratosis but histopathologically unified by the consistent finding of ‘cornoid lamella’. Porokeratosis may develop sporadically due to genetic predisposition or as a result of locally induced immunosuppression. In medical literature, to the best of our knowledge, there are very few reported cases in which lesions of psoriasis were also having cornoid lamella at the margin of the psoriatic lesion and it has recently been described as ‘‘psoriasis encircled by porokeratosis.’’ Here we document a rare case of giant verrucous psoriatic plaque with porokeratosis at the margin in a 25 years old male who was not immunosuppressed and has not received any immunosuppressive treatment such as steroids or photochemotherapy.

Objective: The aim of this work is to evaluate treatment of vitiligo by co-culture of melanocytes derived from hair follicle with adipose-derived stem cells with (NB-UVB) and without (NB-UVB). Patients and methods: In this study, we used co culture of adipose derived stem cell with melanocytes derived from hair follicle in treating different types of stable resistant vitiligo, by two methods transplantation: group (A) exposed to (NB-UVB), group (B) did not expose to (NB-UVB). They are followed up for 3 months. Results: At the end of the follow up period which was 3 months group (A) showed better pigmentary response than group (B) and it was highly statistically significant. Stability, size, site and onset of vitiligo appeared to be important factors affecting treatment results. Using (NB-UVB) also after injection of the treatment showed more improvement in the treatment results. Conclusion: Co-culture of adipose derived stem cell with melanocytes derived from hair follicle could be a safe and effective method of treatment for stable localized vitiligo in patients resistant to other methods of therapy.

Frontal fibrosing alopecia, described simply over two decades in the past, has come to be probably the most normally noticeable causes of scarring phalacrosis at several skilled hair clinics. Regarded a medical variant of lichen planopilaris (LPP), its uncommon components and associations that distinguish it from LPP. Despite the fact that largely affecting post-menopausal ladies, a small however growing number of guys and premenopausal ladies are affected. The spectrum of the ailment has accelerated from involvement of the frontal hairline and eyebrows, to potentially affecting the whole hairline, facial and body hair. Genetic and environmental motives were implicated however the aetiology remains uncertain. A range of cures had been used in management of the, however medical trials are required to set up effectiveness.

Trisomy 8 Mosaicism syndrome, also known as Warkany syndrome 2, is a rare genetic event with an estimated frequency of about 1:25,000 to 1:50,000 births. Complete trisomy 8 is usually lethal, causing 0.70% of first-trimester abortions. However, mosaic trisomy 8 syndrome has extremely variable phenotypes, with a wide range of clinical manifestations, including cranio-facial dysmorphism, mild to severe intellectual disability, multiple skeletal abnormalities, deep palmar-plantar creases, and cardiac-renal abnormalities. A few cases of skin pigmentary anomalies have also been reported. We report on a 36 year old male case with mosaic trisomy 8. He has mild clinical findings and palmo-plantar hypopigmentation, which appears as a demarcating line between his hands’ dorsal and palmar regions. We report this case to investigate palmo-plantar pigmentation anomalies.

Background: Phototherapy has been increasingly used for treatment of acne vulgaris. The targets of the action mechanism of each light treatment are generally thought to be P. acnes. Visible light has been proposed to work by decreasing P. acnes bacterial counts by activating endogenous porphyrins. Objective: To evaluate the effectiveness of phototherapy with Pulsed Light and Heat Energy (LHE) versus topical Adapalene 0.1% in the treatment of mild forms of acne. Method: During the period of 2 years were treated 99 patients with Acne vulgaris, 51 with mild form of Acne vulgaris were treated with Phototherapy and 48 patients with mild form were treated with topical Adapalene 0.1%.The effectiveness was based on the number of inflammatory and non-inflammatory elements in the beginning moment of therapy and in the intervals after two sessions, 4 sessions, 6 sessions, 8 sessions, one month after treatment with Phototherapy and after 2, 4, 6, 8, 10, 12 weeks treatment with Adapalene 0.1% Gel. Results: One month after the treatment with Phototherapy, the inflammatory and non-inflammatory elements cleaning reached 67.9 ± 6.2% in mild form and 68.4 ± 6.5% in moderate form of Acne vulgaris. Three months after the treatment with local treatment, the inflammatory and non-inflammatory elements cleaning reached 59.4 ± 5.8 in mild form and 71.4 ± 7.2 after treatment with local plus systemic in moderate form of Acne vulgaris. Conclusion: The treatment of Acne vulgaris with phototherapy LHE as mono-therapy is a medical alternative which gives good clinical results in a relatively short period of time (one month) and with minimal side effects.

Hair goes grey with chronological aging. Premature hair greying may have significant adverse effects on the appearance, self-esteem, and socio-cultural acceptance of the affected individual. The exact aetiopathogenetic mechanism causing premature greying is still not clear and much speculative. Premature canities may appear alone as an autosomal dominant trait or it may occur in association with certain other disorders. The genes Pax3 and MITE play an important role in melanocyte stem cell maintenance and differentiation. Defective melanosomal transfer to the cortical keratinocytes or melanin incontinence due to melanocyte degeneration is also believed to contribute to greying. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, treatment options still remain far from satisfactory and no effective therapy is available. Premature greying is a feature in a number of well recognised syndromes. A number of other conditions have also been observed to be associated with premature greying of hair.

Demodex spp may cause blepharitis and palpebra skin lesions. Since eyelash demodicosis seems to be quite spreadable in the community, every patient with chronic non-diagnosed blepharitis should be examined for Demodex spp. Tea tree oil treatment may be an efficient and safe therapeutical choice against ocular demodicosis.