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Pulmonary & Respiratory Medicine

ISSN: 2161-105X

Open Access

Volume 9, Issue 3 (2019)

2021 Conference Announcement Pages: 0 - 0

2020 Announcement for Asthma, Allergy and Immunology Conference June 25-26, 2020 Bali, Indonesia

Amelia Smith

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Research Article Pages: 1 - 11

Longitudinal Follow-Up Data on Cotrimoxazole Treatment in Idiopathic Pulmonary Fibrosis and Fibrotic Non-Specific Interstitial Pneumonia

Veronica Varney*, Helen Parnell1, Ginny Quirke, Siva Ratnatheepan, David Salisbury, Ford Brian and Alaa Witwit

Introduction: Studies suggest that cotrimoxazole may have use in patients with idiopathic pulmonary fibrosis
(IPF). We present longitudinal data from our current on-going study, looking at safety and stability of lung function,
oxygen saturations and walking tests out to 6 years.
Methods: Randomization was (double-blind) to cotrimoxazole or placebo for 12 weeks in patients who desaturate
<90% on a shuttle walking test (SWT). At 12 weeks all commence active treatment with out-of-study follow-up and
continued measurement of FVC (forced vital capacity), oxygen saturations and SWT. Data is presented on the first
53 patients.
Results: Tolerance to study drugs was good. Lab based Lung function at 1 year showed significant improvement
from individual baseline entry values for total lung capacity (+600 mls, p=0.0025), residual volume (+723 mls,
p=0.0004) and functional residual capacity (+528 mls, p=0.005). Absolute FVC (+0.5%), vital capacity (+1.5%) and
transfer factor TLCO (-2.0%) showed no significant change, remaining stable at 1 year.
Arterial PO2, SWT and oxygen saturations improved at 12 weeks along with MRC dyspnoea scores. The SGHQIPF
symptom scores improved at 1 year. Mixed effects analyses have shown that relative FVC levels are associated
with a decline by 0.005litres (0.002-0.009) per month on average, Oxygen saturations on air decrease by 0.06%
(0.03-0.09) per month and SWT by 2.3metres (1.10-3.48) per month.
Conclusion: Cotrimoxazole was well tolerated. Total lung capacity improved by a mean of + 10.7% at 1
year along with residual volume +25.6%. Symptom scores significantly improved but there was no reduction in
radiographic changes. This data has fulfilled 2 of the 3 required criteria by the ATS/ERS statement (2000) for a
favourable response. Cotrimoxazole may be a useful alternative in patients intolerant of the anti-fibrotic drugs.

Case Report Pages: 1 - 3

A Case of PE Mimicking Community Acquired Pneumonia and Pulmonary Neoplasm

Mais Al-Sardi, Doaa Al-Faifi, Mohammed Hashim Khalafallah and Abdulaziz Nwasser Al-Huraqi*

There are many mimickers to community acquired pneumonia and pulmonary embolism is one of them. It’s important to acknowledge patients complaints and when facing non-resolving pneumonia an alternative diagnosis should be considered. Early diagnosis leads to early treatment which reduces the mortality of PE.

Google Scholar citation report
Citations: 1690

Pulmonary & Respiratory Medicine received 1690 citations as per Google Scholar report

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