Transplantation Technologies & Research

Chronic Granulomatous Disease (CGD) is a rare, inherited immunodeficiency disorder characterized by dysfunctional phagocytes, rendering affected individuals highly susceptible to recurrent and severe infections. Hematopoietic Stem Cell Transplantation (HSCT) has emerged as a promising curative therapy for CGD, offering the potential for restored immune function. This review explores the clinical application of HSCT in CGD, analyzing the historical and contemporary aspects of the procedure, associated challenges and patient outcomes. Keywords include risk assessment, donor selection, Graft-Versus-Host Disease (GVHD), conditioning regimens and long-term follow-up. The findings underscore the significance of HSCT as a potentially curative approach for CGD, while emphasizing the importance of continued research and multidisciplinary collaboration for optimal patient care.

Lung transplant recipients represent a vulnerable population at the intersection of autoimmunity and the COVID-19 pandemic. This review explores the complex interplay between post-transplant autoimmunity and COVID-19 in lung transplant recipients. We analyse the unique challenges faced by these patients, including increased susceptibility to infections, potential exacerbation of autoimmune reactions and the impact of immunosuppressive therapies. Key considerations include risk assessment, vaccination strategies and the evolving landscape of management protocols. By navigating this crossroads with a multidisciplinary approach that integrates immunology, transplantation and infectious disease expertise, healthcare providers can optimize patient care and outcomes.

Solid organ transplant recipients are at an increased risk of developing skin cancer due to long-term immunosuppressive medication use. This review explores the complex relationship between immunity, immunosuppressive drugs and the occurrence of Non-Melanoma Skin Cancers (NMSCs) in transplant recipients. We analyze key factors affecting skin cancer risk, including type and dosage of immunosuppressive medications, as well as individual patient characteristics. The literature review suggests that achieving a delicate balance between preventing graft rejection and reducing skin cancer risk is a challenge. We discuss strategies for mitigating NMSC risk, such as the use of alternative immunosuppressive regimens and vigilant dermatological monitoring. Ultimately, a multidisciplinary approach is required to ensure the overall well-being of transplant recipients.

Congenital glaucoma is a rare but severe ocular condition that can lead to vision impairment or blindness if left untreated. Penetrating Keratoplasty (PKP) has emerged as a viable surgical option to restore vision in individuals with congenital glaucoma who present with corneal opacity. This paper presents a comprehensive review of the surgical procedure, outcomes and challenges associated with PKP in congenital glaucoma. Through an extensive literature review, we examine the key factors influencing surgical success, such as patient selection, donor corneal grafts and postoperative management. We discuss the potential complications and long-term outcomes while emphasizing the importance of early intervention and long-term follow-up in achieving optimal results. In conclusion, PKP offers a promising approach for vision restoration in congenital glaucoma patients and serves as a crucial component of a multi-disciplinary approach in managing this challenging condition.