Medicinal Chemistry

Study of carbon containing molecules is the scientific study of the structure, properties, composition, reactions, preparation for carbon-based compounds, carboniferous, and their out growth. These compounds may be contain any number for other molecules, including methanol, nitrogen, oxygen, the halogens as well as phosphorus, silicon

We are happy to announce the event "International Conference on Pure & Applied Chemistry" scheduled during October 19-20, 2020 at Tokyo, Japan with a theme of “Exploring the Research Challenges and Advancements in Applied Chemistry”. We invite you all to Applied Chemistry 2020 to have incredible associations with the effective professionals.

These days many people are suffering from many non-communicable diseases like hypertension, diabetes, ethanol induced liver injury and several types of cancers. There is no absolute cure and effective modern medicine for the above mentioned non-communicable diseases. Garlic is one of the most commonly used bulb crop used in different parts of the world as a spice, traditional medicine and food additive. This plant is a species in the onion genus, Allium, and many studies proved that this plant could be used in the treatment of many non-communicable diseases and is safe for human use

Malaria is still a major public health problem in the world causing high morbidity and mortality in sub-saharan Africa mainly on less than five years of age. Thus, there is still a need to search for new and more effective antimalarial drugs against drug-resistant Plasmodium strains. Natural products have been the main source for the search of new antimalarial drugs. This study evaluates the antiplasmodial activity of some selected medicinal plant traditionally used for the treatment of malaria in Ethiopia. The aqueous and methanol crude extracts were prepared by cold maceration technique. The acute toxicity of the extracts was conducted on mice according to OECD guide line. The antiplasmodial activity of each plant extract was assessed by the classical 4day Suppressive test and The body weights and survival time was also recorded throughout the follow-up period. The result of 4-day suppressive test revealed that the methanol and aqueous extracts of Croton macrostachyus, Vernonia amygdalina, Calpurnia aurea, and, the leaf latex of A. debrana had antiplasmodial activity. All the extracts showed a significant (p<0.01) parastemia inhibition at a dose of 400 mg/kg compared to negative control group. The highest antiplasmodial activity was recorded from the leaf extracts of V. amygdalina (42.26%) at 400 mg/kg dose. All the mice treated with the tested plant extracts showed protection of the mice from body weight loss. The acute toxicity study showed there was no mortality recorded at a dose of 5000 mg/kg. The result of this study indicates that the plants have antimalarial activities. This confirms the traditional claims utilization of the plant for malaria treatment. It needs further activity guided isolation and characterization and antimalarial activity and toxicity studies.