Medicinal Chemistry

Natural products have long served as a rich source of lead compounds for drug discovery and development. However, their inherent limitations, such as poor bioavailability, selectivity and metabolic instability, often hinder their clinical utility. Medicinal chemistry strategies play a pivotal role in overcoming these challenges by modifying bioactive natural products to enhance their pharmacological properties. This article provides an overview of various medicinal chemistry approaches employed for the modification of bioactive natural products, including structural optimization, semi-synthesis, prodrug design and molecular hybridization. Case studies highlighting successful examples of these strategies in drug development are also discussed.

The aryltetralin derivatives were extracted from plant and also synthesized using tetralone as a starting material. They were synthesized by replacing 1,3-methylene dioxy ring with dimethoxy, hydroxy, methyl, chlorine, hydrogen and methoxy group. The structure of the final compounds was confirmed by ¹H NMR, ¹³C NMR, mass spectra and elemental analysis data and the analogues were screened for anti-diabetic activity. It is noteworthy all the synthesized derivatives exhibits good anti-diabetic activity with respect to extracted aryltetralin compound.

Copper, an essential trace element, plays a pivotal role in various biological processes. However, excess copper levels can lead to cytotoxicity, causing oxidative stress and cell damage. One crucial determinant of copper-induced cytotoxicity is its reduction potential, influencing its redox activity within cells. This article delves into the intricate relationship between copper reduction potential and reductive cytotoxicity, exploring underlying mechanisms, implications for health and potential therapeutic interventions.

Metabolomic profiling has emerged as a powerful tool in understanding the molecular intricacies of various diseases, including Endometrial Cancer (EC) and hyperplasia. This article explores recent advancements in metabolomic profiling of blood plasma in females with hyperplasia and EC, highlighting the potential of metabolomics in early detection, prognosis and personalized treatment strategies for these conditions.

Immunomodulatory peptides have garnered significant attention in recent years for their dual role as vaccine adjuvants and antimicrobial agents. This article explores the potential of these peptides in enhancing vaccine efficacy and combating microbial infections. We delve into their mechanisms of action, applications in vaccine development and their effectiveness against various pathogens. Furthermore, we discuss the challenges and future prospects of immunomodulatory peptides in the field of immunotherapy and infectious disease management.