Department of Surgery and Transplantation, University Hospital of Udine, Udine, Italy
Anna Rossetto works for Department of Surgery and Transplantation, University Hospital of Udine, Udine, Italy..LOSTRIDIAL neurotoxins, including tetanus toxin and the seven serotypes of botulinum toxin (A–G), are produced as single chains and cleaved to generate toxins with two chains joined by a single disulphide bond (Fig. 1). The heavy chain (Mr 100,000 (100K)) is responsible for specific binding to neuronal cells and cell penetration of the light chain (50K), which blocks neurotransmitter release1–9.
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