Environmental & Analytical Toxicology

Abdel-Tawab H Mossa

Publications

• Research Article
  Protective Effects of Vitamin C against Methomyl-Induced Injures on the Testicular Antioxidant Status and Apoptosis-Related Gene Expression in Rat
  Author(s): Tarek M Heikal, Abdel-Tawab H Mossa and Wagdy KB KhalilTarek M Heikal, Abdel-Tawab H Mossa and Wagdy KB Khalil
  
  The present study is undertaken to evaluate the protective effects of vitamin C (VC) against methomyl-induced oxidative stress and testicular injures in Wister rat. Male rats were randomly divided into 4 groups of 6 rats each. The route of application selected for the study was oral gavage for 28 consecutive days. Group 1 was served as a control, whereas group 2 was supplemented with VC (200 mg kg-1 body weight, bw). Group 3 was administered with a dose of methomyl equivalent to 1/10 LD50 (2.034 mg kg-1 bw), whereas group 4 was co-administered VC and methomyl as the same dose of groups 2 and 3, respectively. Sub-acute exposure of rats to methomyl for 28 consecutive days resulted in a significant increase in testicular lipid peroxidation (LPO) and a decrease in glutathione (GSH) level. In addition, the testicular activities of catalase (CAT), superoxide dismutase (SOD) and glutathione-.. Read More»
  DOI: 10.4172/2161-0525.1000255

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