Molecular and Genetic Medicine

Abeer Sheneef

Publications

• Research Article
  Association of Interleukin-10 (-592A/C) Gene Polymorphism with its Level in Type 2 Diabetes Mellitus with and without Nephropathy
  Author(s): Aida A Mahmoud, Abeer Sheneef, Ayat A. Sayed, Mohamed AW Ezat and Eman A SabetAida A Mahmoud, Abeer Sheneef, Ayat A. Sayed, Mohamed AW Ezat and Eman A Sabet
  
  Objectives: Several candidate genes are implicated in the pathogenesis of type 2 diabetes mellitus (T2DM), one of which is interleukin (IL-10). In this investigation, we aimed to study the association between IL-10 (-592A/C) gene polymorphism with its level in T2DM with and without nephropathy. Methods: IL-10 (-592A/C) gene polymorphism was genotyped using restriction fragment length polymorphism (RFLP-PCR) technique and IL-10 levels were measured in two groups of T2DM, one group complicated with nephropathy and the second non-complicated. Results: Our results revealed no significant differences in IL-10 (−592A/C) genotypes distribution between the two groups of T2DM patients. IL-10 levels were found significantly elevated in diabetic nephropathy patients compared to T2DM without nephropathy (P<0.05) and were positively correlated to the degree of albuminu.. Read More»
  

  Abstract PDF