Pulmonary & Respiratory Medicine

Aishwarya Thakur

Publications

• Research Article
  Circulating Aldosterone Levels and Disease Severity in Pulmonary Arterial Hypertension
  Author(s): Zeenat Safdar, Aishwarya Thakur, Supriya Singh, Yingqun Ji, Danielle Guffey, Charles G Minard and Mark L EntmanZeenat Safdar, Aishwarya Thakur, Supriya Singh, Yingqun Ji, Danielle Guffey, Charles G Minard and Mark L Entman
  
  Objectives: It is not known whether aldosterone levels are associated with increased mortality in patients with pulmonary arterial hypertension (PAH). The primary goal of this study was to determine whether circulating aldosterone levels predict severity of PAH in terms of hemodynamic characteristics and mortality. Methods: Patients with stable PAH were enrolled at the Baylor PH program. The plasma levels of aldosterone and BNP were measured. Clinical, hemodynamic, and outcome data was collected by chart review. Mean follow up time from study enrollment was 39 ± 102 months. Cox proportional hazards model was used to assess time to death. Results: There were 125 PAH patients with plasma aldosterone levels. Median aldosterone level was 9.9 pg/ml (25th-75th percentile: 4.1 pg/ml, 27.1 pg/ml) and median brain natriuretic peptide (BNP) level was .. Read More»
  

  Abstract PDF