Journal of Nephrology & Therapeutics

Ajmal MS

Publications

• Case Report
  Metformin Toxicity in Acute Kidney Injury. A Rare Cause of Severe Lactic Acidosis
  Author(s): Ajmal MS, Vinod S and Yan JAjmal MS, Vinod S and Yan J
  
  Metformin a biguanide derivative is the preferred initial pharmacologic agent for the treatment of type 2 diabetes mellitus per current guidelines of the American Diabetes Association. It is prescribed to an estimated 120 million people worldwide. Type B lactic acidosis is a reported but rare side effect of Metformin use. Serum Metformin level is not routinely monitored or available in most hospitals, but it can be a useful test to confirm the diagnosis and guide future use of Metformin in at risk patients. We present a case of a 78-year old African American diabetic female on prescribed dose of Metformin with no history of kidney disease who presented with acute encephalopathy and hemodynamic instability. Her laboratory data showed acute kidney injury (AKI) with severe lactic acidosis (LA). She required large amount of intravenous bicarbonate infusions and urgent initiation of Contin.. Read More»
  DOI: 10.37421/jnt.2019.9.332

  Abstract PDF