Cancer Science & Therapy

Akimitsu Takagi

Publications

• Review Article
  Multicellular Spheroid Culture Models: Applications in prostate Cancer Research and Therapeutics
  Author(s): Daisuke Kurioka, Akimitsu Takagi, Misao Yoneda, Yoshifumi Hirokawa, Taizo Shiraishi and Masatoshi WatanabeDaisuke Kurioka, Akimitsu Takagi, Misao Yoneda, Yoshifumi Hirokawa, Taizo Shiraishi and Masatoshi Watanabe
  
  Prostate cancer is one of the most prevalent cancers in men in Western countries, increasing in frequency with age through the most advanced years. Patients with localized prostate cancer are generally treated with radical prostectomy or radiation therapy. However, treatment of more malignant stages of the disease is problematic. Docetaxel-based chemotherapy in men with androgen-independent prostate cancer has been shown to have survival benefits but hormonal manipulation and other chemotherapeutic regimens, especially for androgen-independent lesions, have uncertain value. While research into the complex pathophysiology of advanced prostate cancer has led to identification of mechanisms and target molecules, it nevertheless remains necessary to develop new anticancer drugs. Cell culture models that mimic the structure and features of prostate cancer in vivo are necessary for research.. Read More»
  DOI: 10.4172/1948-5956.1000059

  Abstract PDF