Cancer Science & Therapy

Akulapalli Sudhakar

Publications

• Research Article
  From Normal Cells to Malignancy: Distinct Role of Pro-inflammatory Factors and Cellular Redox Mechanisms
  Author(s): Rajendra K Singh, Akulapalli Sudhakar and Bal L LokeshwarRajendra K Singh, Akulapalli Sudhakar and Bal L Lokeshwar
  
  The genesis of many solid cancers is a complex, multistep process that includes cellular neoplastic transformation, resistance to apoptosis, loss of control of cell cycle, angiogenesis and acquisition of invasive properties. Among a number of factors, the simultaneous existence of chronic inflammatory mechanism and downregulation of antioxidant defense mechanism of cells are emerging major causes of neoplastic transformation and the progression of many solid cancers. The Longer the inflammation persists, higher the risk of developing many age related malignancies such as organs of colon, stomach and prostate etc. Concurrent occurrence of these processes that may affects DNA mutations in cells by excessive generation of free radicals, Reactive Oxygen Species (ROS) and other active intermediates that exceed the limit of the cells ability to neutralize it. Chronic inflammatory conditions.. Read More»
  DOI: 10.4172/1948-5956.1000061

  Abstract PDF