Cancer Science & Therapy

Alastair J Munro

Publications

• Research Article
  Intensity Modulated Radiation Therapy (IMRT) in the Treatment of Squamous Carcinoma of the Oropharynx: An Overview
  Author(s): Sourav Guha, Charles G Kelly, Rajdeep Guha, Rimpa Achari, Indranil Mallick, Vinidh Paleri, Alastair J Munro and Sanjoy ChatterjeeSourav Guha, Charles G Kelly, Rajdeep Guha, Rimpa Achari, Indranil Mallick, Vinidh Paleri, Alastair J Munro and Sanjoy Chatterjee
  
  Background: Intensity Modulated Radiotherapy (IMRT) is being used increasingly for the radical treatment of oropharyngeal cancers. We have reviewed the evidence and summarised the data to enable readers to decide whether the dosimetric advantages of IMRT have been translated into clinical benefit in oropharyngeal cancer treatment. Methods: We searched Medline and the Cochrane library for published studies investigating the role of IMRT in reducing rates of xerostomia, osteoradionecrosis and difficulties with swallowing. Results: Despite heterogeneity in the assessment of xerostomia following radiotherapy, 20 out of the 22 studies reported lower xerostomia rates following parotid-sparing IMRT. There is only limited information on the consequences of sparing dose to the submandibular gland and emerging clinical informati.. Read More»
  DOI: 10.4172/1948-5956.1000115

  Abstract PDF