Nuclear Medicine & Radiation Therapy

Alastair Law

Publications

• Research Article
  Improved Outcomes for Prostate Cancer Using Hypofractionated Radiotherapy and Dose Escalation to 55Gy
  Author(s): Joanna Mackenzie, Alastair Law, Jahangeer Malik, Gill Kerr, Grahame Howard, Geoff Higgins and Duncan MclarenJoanna Mackenzie, Alastair Law, Jahangeer Malik, Gill Kerr, Grahame Howard, Geoff Higgins and Duncan Mclaren
  
  Abstract Introduction: This Centre has previously reported outcomes for patients treated with neoadjuvant hormone therapy (NAHT) and 52.5Gy in 20 fractions. We now present the outcome data for patients treated with 55Gy in 20 fractions and NAHT. Methods and Materials: 584 patients were treated for T1-T3 node negative prostate cancer. The median age was 67.2 years (range 49-80). All patients received 3 months of NAHT followed by CT planned conformal radiotherapy to the prostate using 55Gy in 20 fractions. 147 patients considered at particularly high risk of relapse also received 2 years of adjuvant androgen deprivation. Outcomes were obtained through serial PSA measurement. Patients were classified into prognostic groups according to Zelefsky criteria. PSA relapse was defined according to Houston criteria. The outcomes with 55Gy were compared with the 52.5Gy cohort. .. Read More»
  DOI: 10.4172/2155-9619.1000188

  Abstract PDF