Cardiovascular Diseases & Diagnosis

Alberto C. Frati Munari

Publications

• Review Article
  Inflammation, Metalloproteinases, Chronic Venous Disease and Sulodexide
  Author(s): Alberto C. Frati Munari and Luis Fernando Flota CerveraAlberto C. Frati Munari and Luis Fernando Flota Cervera
  
  Abstract Inflammation and extracellular Matrix Metallo Proteinases (MMPs) have been recently considered as an important step in the pathogenesis of Chronic Venous Disease (CVD). To understand how inflammation and MMP may affect venous tissue, a review on these items and on the pathogenesis of CVD was performed. Prolonged or repeated venous hypertension due to well-known predisposing factors causes abnormal shear stress leading to shredding of endothelial glycocalyx and activation of endothelial cells. The latter expose adhesion molecules and release pro-inflammatory cytokines. Diapedesis follows, leading to leukocytes infiltration of Extra Cellular Matrix (ECM) in the sub endothelial space of vein walls and valves. Activated leukocytes, mainly monocytes-macrophages, release chemotactic cytokines that amplify the inflammatory response, they also produce Nitric Oxide molecules (NO) and .. Read More»
  DOI: 10.4172/2329-9517.1000203

  Abstract PDF