Journal of Bioengineering & Biomedical Science

Aldredge CR

Publications

• Research Article
  Effects of Matrix Metalloproteinase on Tumour Growth and Morphology via Haptotaxis
  Author(s): Aldredge CR and Nargis NNAldredge CR and Nargis NN
  
  A tumour invasion model has been developed to examine the influence of diffusible matrix metalloproteinases (MMPs) and the mediated proteolysis of non-diffusible, membrane type MMPs (MT-MMPs) on tumour growth and morphology via haptotaxis. Our results are the first to explore the influence of localized degradation of extracellular matrix (ECM) by MT-MMPs on the morphology of tumours growing in nutrient-rich and nutrient-poor microenvironments. Two-dimensional numerical simulation, using a level-set-based tumour host interface-capturing method, reveals that haptotaxis due to ECM degradation by MMP causes greater instability than with ECM degradation by MT-MMP in low-nutrient environments, even at low proliferation rates; whereas the resulting morphologies are similar for high apoptosis rates. Our simulation results show that while haptotaxis leads to completely different tumour growth .. Read More»
  DOI: 10.4172/2155-9538.1000207

  Abstract PDF