Nuclear Medicine & Radiation Therapy

Alec Weiss

Publications

• Special Issue Article
  Patient Specific 3D Image-Based Radiation Dose Estimates for 90Y Microsphere Hepatic Radioembolization in Metastatic Tumors
  Author(s): Andrew Kennedy, William Dezarn and Alec WeissAndrew Kennedy, William Dezarn and Alec Weiss
  
  Introduction: Hepatic brachytherapy using either resin or glass 90Y microspheres is an established therapy for unresectable primary and metastatic tumors. Unlike conventional brachytherapy, microsphere brachytherapy has no software currently available for pretreatment evaluation and radiation planning. A non-MIRD radiation dose calculation approach is desired to accurately utilize spatial relationships in the liver and tumor distribution. Materials and methods: A newly developed software tool employing the technetium-99m macro aggregated albumin (99mTc-MAA) SPECT 3-D dataset and CT scan was used to estimate the likely absorbed dose in normal liver and tumor tissue from 90Y microsphere brachytherapy (radioembolization). Monte Carlo algorithms were utilized to maximize true 3D dose estimates for each patient's unique liver and tumor geometry. Clinical correlation was completed regardi.. Read More»
  DOI: 10.4172/2155-9619.1000111

  Abstract PDF