Journal of Nephrology & Therapeutics

Alessandra Nunzi

Publications

• Review Article
  Glomerulonephritis, Pathogenetic Mechanisms and Therapeutic Options: An Overview
  Author(s): Gaspare Elios Russo, Tania Gnerre Musto, Massimo Testorio, Alessio Molfino, Andrea Martinez, Alessandra Nunzi, Virgilio DeBono, Dmytro Grynyshyn, Annarita D’Angelo, Georgie Innico and S. LaiGaspare Elios Russo, Tania Gnerre Musto, Massimo Testorio, Alessio Molfino, Andrea Martinez, Alessandra Nunzi, Virgilio DeBono, Dmytro Grynyshyn, Annarita D’Angelo, Georgie Innico and S. Lai
  
  Introduction: Most forms of human glomerulonephritis (GN) result from immunologic mechanisms that are mediated by the actions of multiple elements of both the innate and adaptive immune systems, thereby resulting in different clinical manifestations. The treatment of immune-mediated kidney disease is based on steroids and immunosuppressive drugs that interfere with the immune processes. These groups of drugs have led to significant benefits, but severe side effects are still frequent. Monoclonal antibodies directed against molecules of inflammation or several cellular components have emerged in clinical practice. Plasmapheresis and new methods to reduce the risks associated with the procedure with standard therapies may be combined. Moreover new therapeutic options have been proposed, as the use of natural anti-inflammatory cytokines or in.. Read More»
  DOI: 10.4172/2161-0959.1000175

  Abstract PDF