Journal of Blood & Lymph

Alex Stentz

Publications

• Research Article
  Chromosome 1 Abnormalities Predict Shortened Progression Free and Overall Survival in Patients with High Risk Multiple Myeloma Undergoing Autologous Hematopoietic Cell Transplantation, a Retrospective Analysis
  Author(s): Emma C. Scott, Yiyi Chen, Andy I. Chen, Stephen D. Smith, Ido Barkay, William Dibb, Alex Stentz, Rachel Frires, Matthew Siegel, Phoebe Trubowitz, Eva Medvedova and Richard T. MaziarzEmma C. Scott, Yiyi Chen, Andy I. Chen, Stephen D. Smith, Ido Barkay, William Dibb, Alex Stentz, Rachel Frires, Matthew Siegel, Phoebe Trubowitz, Eva Medvedova and Richard T. Maziarz
  
  Abnormalities of chromosome (ch)1 have been shown to be significant adverse prognostic factors in multiple myeloma (MM) but they have not yet been systematically studied in patients undergoing autologous hematopoietic cell transplantation (auto-HCT). The aim of this study was to determine whether patients with high-risk MM and ch1 abnormalities (1q gain, 1p deletion, translocations of ch1) constitute a highest risk group compared to a contemporaneous cohort of high-risk MM patients without ch1 abnormalities. 232 patients (169 induction, 63 salvage) with MM and at least one recognized high-risk feature met criteria for inclusion. The presence of a ch1 abnormality (n=15) was highly significant in patients undergoing salvage autologous HCT (n=6) for predicting shorter PFS (p<0.001; HR= 22.93; 95% CI: 4.94- 106.48), and OS (p = 0.0002; HR= 21.22; 95% CI: 1.18-14.98). Median PFS and OS .. Read More»
  DOI: 10.4172/2165-7831.1000131

  Abstract PDF