Nuclear Medicine & Radiation Therapy

Alexander R Mackay

Publications

• Review Article
  Treatment of Brain Metastases: Past, Present and Future Directions
  Author(s): Ameer L Elaimy, John J Demakas, Alexander R Mackay, Wayne T Lamoreaux, Robert K Fairbanks, Barton S Cooke and Christopher M LeeAmeer L Elaimy, John J Demakas, Alexander R Mackay, Wayne T Lamoreaux, Robert K Fairbanks, Barton S Cooke and Christopher M Lee
  
  Brain metastases are the most frequently observed cancerous lesions in the brain and their incidence has grown as advances in imaging technologies and the treatment of extracranial disease has allowed the life expectancy of cancer patients to increase. For this reason, determining optimal treatment regimens for specific subsets of patients with brain metastases is imperative for clinicians. The purpose of this article is to review the randomized controlled trials analyzing patients with brain metastases treated with neurosurgery, WBRT, and SRS to determine future research directions for physicians and scientists. For patients who have a Karnofsky Performance Status (KPS) ≥70 and a single, surgically accessible brain metastasis, surgical resection followed by post-operative WBRT has proven to be a superior treatment modality when compared to WBRT alone and surgical res.. Read More»
  DOI: 10.4172/2155-9619.S2-002

  Abstract PDF