Pulmonary & Respiratory Medicine

Algarté-Génin M

Publications

• Research Article
  Identification of Two Novel Regulatory Elements in the IL2RA Gene Locus
  Author(s): Rosa F, Rameil P, Algarté-Génin M, Bedotto M, Ferrier P, Cauchy P and Imbert JRosa F, Rameil P, Algarté-Génin M, Bedotto M, Ferrier P, Cauchy P and Imbert J
  
  Regulatory T-cells (Tregs) express the high-affinity chain of the interleukin 2 (IL-2) receptor, CD25, encoded by the IL2RA gene. IL2RA is one of the most extensively characterized genes regarding its regulatory regions and their functional links to cell surface receptors and their associated signal transduction cascade in the context of the antigen-dependent activation of mature CD4+ T lymphocyte. However, converging evidences strongly suggested that they were some missing pieces in this already complex puzzle made of 6 well-characterized regulatory regions. Here, by combining principally in silico genomic footprinting approach and meta-analysis of several ChIP-seq studies, we identified and characterized 2 new putative CD28-responsive elements. We show that a recently-characterized intronic enhancer at +11 kb harbors a functional CREB site. Further, we evidence a r.. Read More»
  DOI: 10.4172/2161-105X.1000458

  Abstract PDF