Journal of Hypertension: Open Access

Alice Valença Araújo

Publications

• Research Article
  Function and Protein Expression of Potassium Channels in Mesenteric Resistance Arteries Isolated from 2K-1C Hypertensive Rats
  Author(s): Alice Valença Araújo, Marcella D Grando, Roberto S DA Silva and Lusiane M BendhackAlice Valença Araújo, Marcella D Grando, Roberto S DA Silva and Lusiane M Bendhack
  
  The present study aimed to evaluate the K+ channels activation in vascular relaxation induced by the nitric oxide (NO) donors ruthenium-derived complex (Terpy) and sodium nitroprusside (SNP), as well as its protein expression, on mesenteric resistance arteries (MRA) isolated from renal hypertensive rats (2K-1C) and sham-operated rats (Sham). The NO donors Terpy and SNP induced relaxation with similar efficacy in isolated MRA from both 2K-1C and Sham rats, although SNP was more potent than Terpy. The maximum relaxation induced by Terpy was decreased when the voltagegated potassium channels were blocked in MRA from Sham, but not in 2K-1C rat arteries. The blockade of ATP-sensitive (KATP), big and small conductance Ca2+-activated (SKCa) or inward rectifier (KIR) potassium channels decreased the maximum relaxation induced by Terpy in MRA from Sham and 2K-1C rats. However, the maximum rela.. Read More»
  DOI: 10.4172/2167-1095.1000146

  Abstract PDF