Medicinal Chemistry

Amit Beniwal

Publications

• Research Article
  Docking Studies and Evaluation of Anthranilic Acid Based PPARδ Agonists for the Treatment of Metabolic Syndromes
  Author(s): Meenu Beniwal, Viney Lather, Vikramjeet Judge, Neelam Jain and Amit BeniwalMeenu Beniwal, Viney Lather, Vikramjeet Judge, Neelam Jain and Amit Beniwal
  
  Metabolic syndrome (MS) is defined by a cluster of interconnected factors that directlyincrease the risk of coronary heart disease (CHD), other forms of cardiovascularatherosclerotic diseases (CVD) and Type 2 diabetes mellitus (T2DM). Several studies have suggested important role of PPARδ in regulating lipid metabolism and energy homeostasis in muscle and fat. The present research work was undertaken to design and develop novel moieties derived from anthranilic acid scaffold as PPARδ agonists that can be developed further for the management of metabolic disorders. The molecules were designed using receptor based drug design approach, by utilizing the X-ray crystallographic information of PPARδ from PDB database. Based on the pharmacophoric requirements for PPARδ binding, the anthranilic acid nucleus was chosen for the design of newer analogs by.. Read More»
  DOI: 10.4172/2161-0444.1000318

  Abstract PDF