Medicinal Chemistry

Anca Rusu

Publications

• Research Article
  Interleukin 17 and Pro-hepcidin in Anemia and Erythropoietin Responsiveness of Chronic Kidney Disease Patients Treated with Hemodialysis
  Author(s): Anca Rusu, Ina Kacso, Simona Racasan and Mirela Gherman CaprioaraAnca Rusu, Ina Kacso, Simona Racasan and Mirela Gherman Caprioara
  
  Background: Monocytes and granulocytes, activated by contact with hemodialysis membranes, generate increased cytokine secretion, an important key in pathogenesis of anemia and erythropoietin (rHuEPO) resistance. We aimed to examine the correlation of IL-17 and pro-hepcidin with anemia of chronic kidney disease (CKD) patients treated with hemodialysis(HD). Method: 69 HD patients were included. Exclusion criteria were: neoplasia, acute infections, blood loss, absolute iron deficiency. IL-17 and pro-hepcidin were determined. Hemoglobin, ferritin, transferrin and transferrin saturation were measured. rHuEPO responsiveness index was calculated. A poor response to rHuEPO was defined as rHuEPO responsiveness index>200. Results: Mean level of IL-17 was .. Read More»
  DOI: 10.4172/2161-0444.1000277

  Abstract PDF