Journal of AIDS & Clinical Research

Andreas Lind

Publications

• Research Article
  Comparable Cellular Immune Responses in Patients with and without Antiretroviral Treatment after Immunization with HIV-1 P24, P17 and Tat Consensus Peptides (Vacc-5q)
  Author(s): Anne-Marte B Kran, Andreas Lind, Maja M Sommerfelt, Ingebjørg Baksaas, Birger Sørensen and Dag KvaleAnne-Marte B Kran, Andreas Lind, Maja M Sommerfelt, Ingebjørg Baksaas, Birger Sørensen and Dag Kvale
  
  Objectives: Therapeutic vaccination in chronic HIV-infection aims to attenuate disease progression by promoting new HIV-specific T cell-clones. Most clinical trials with therapeutic vaccines are conducted on patients receiving antiretroviral therapy (ART). However, studies of vaccination in untreated individuals are limited. We present the first data from a phase I/II clinical trial with a peptide-based therapeutic vaccine (Vacc-5q) consisting of five short, modified consensus peptides from p17, p24, and Tat. In addition to evaluating safety and immunogenicity of Vacc-5q, we compared responses induced in patients on effective ART with those of ART-naïve patients. Methods: HIV-infected patients stable on ART (n=10) and treatment naive patients (n=10) received 11 intradermal injections of Vacc-5q over 26 weeks, using GM-CSF as an adjuvant. Immunogenicity was assessed both i.. Read More»
  DOI: 10.4172/2155-6113.1000296

  Abstract PDF