Journal of Biometrics & Biostatistics

Andrew Dittmore

Publications

• Research Article
  Locating CpG Islands with Kullback-Leibler Divergence
  Author(s): Yung-Pin Chen, Andrew Dittmore, Yasuhiro Goda, Alicia Laughton and Jessica MinnierYung-Pin Chen, Andrew Dittmore, Yasuhiro Goda, Alicia Laughton and Jessica Minnier
  
  A CpG island is a short contiguous DNA subsequence that is rich in CG dinucleotides. CpG islands are often located around the promoters of housekeeping genes and have been found associated with certain tissue-specific genes. This observation indicates that they can be used as markers to identify genes. The information about the locations of CpG islands can also help us understand a gene regulation process called methylation. In this report, we propose a statistical method for locating CpG islands. Our method employs the Kullback-Leibler divergence. We use the given DNA sequence to determine a window size and a shift size for computing the divergence values along a DNA segment. A region in the proximity of a CpG island should contain consecutive windows with high divergence values. The distribution of the Kullback-Leibler divergence values can be suitably fitted by a truncated Pareto d.. Read More»
  DOI: 10.4172/2155-6180.1000148

  Abstract PDF