Journal of Bioengineering & Biomedical Science

Andrés E Castell-Rodríguez

Publications

• Research Article
  Structural Effect of Different EDC Crosslinker Concentration in Gelatin- Hyaluronic Acid Scaffolds
  Author(s): Katia Jarquín-Yáñez, Jesús Arenas-Alatorre, Gabriela Piñón-Zárate, Rosa María Arellano-Olivares, Miguel Herrera-Enríquez, Beatriz Hernández-Téllez and Andrés E Castell-RodríguezKatia Jarquín-Yáñez, Jesús Arenas-Alatorre, Gabriela Piñón-Zárate, Rosa María Arellano-Olivares, Miguel Herrera-Enríquez, Beatriz Hernández-Téllez and Andrés E Castell-Rodríguez
  
  Introduction: Gelatin and hyaluronic acid are two biopolymers with different applications in tissue engineering. They may be employed to construct diverse scaffolds that allow cells to differentiate and proliferate on them. In order to obtain the best functional and mechanical conditions in scaffolds, they must be crosslinked to form covalent links between gelatin and hyaluronic acid. The crosslinker 1-ethy-3-(3-dymethylaminopropyl) carbodiimide hydrochloride (EDC) is a compound widely used due to its low cytotoxicity. Besides, the concentration of the crosslinker may modify the physical properties and morphological characteristics of scaffolds when it forms covalent links between biopolymers, helping to construct different kinds of scaffolds used for developing soft tissues. However, the development of scaffolds made of gelatin and hyaluronic acid crosslinked with ED.. Read More»
  DOI: 10.4172/2155-9538.1000182

  Abstract PDF