Journal of Clinical & Medical Genomics

Ann L Craddock

Publications

• Research Article
  Gene Variability between Perineural-Positive and Perineural-Negative Squamous Cell Skin Cancers
  Author(s): Ashley C Mays, Jeff Chou, Ann L Craddock, Lance Miller and J Dale BrowneAshley C Mays, Jeff Chou, Ann L Craddock, Lance Miller and J Dale Browne
  
  Background: Recurrent cutaneous squamous cell cancer (CSCC) is associated with poor outcomes with perineural invasion reported as a frequent finding in such lesions. Given the morbidity associated with late recurrence, identifying aggressive subtypes of CSCC at the time of primary excision is all the more necessary. This project sought to identify differentially expressed genes (DEGs) between perineural invasion-positive (PP) and perineural invasion-negative (PN) CSCC. Gene-based classification models for diagnosis of perineural invasion in CSCC were also developed. Method: Forty fresh-frozen surgical specimens of CSCC with presence or absence of histopathological perineural invasion were processed for RNA isolation and hybridization to Affymetrix-U219 DNA microarrays. Raw gene expression data were normalized by Robust Multi-array Averaging .. Read More»
  DOI: 10.4172/2472-128X.1000133

  Abstract PDF