Journal of Tissue Science and Engineering

Anne Glashauser

Publications

• Research Article
  Promoting and Harmful Effects of Steroid Hormones on Renal Stem/Progenitor Cell Development
  Author(s): Will W. Minuth, Lucia Denk and Anne GlashauserWill W. Minuth, Lucia Denk and Anne Glashauser
  
  In regenerative medicine much attention is given to stem/progenitor cells for a future therapy of acute and chronic renal failure. However, up to date sound cell biological knowledge about nephron renewal within the diseased kidney is lacking. Of special interest are steroid hormones occurring in the interstitial fluid. It is unknown, if they have promoting or hampering effects on the development of stem/progenitor cells. To investigate the influence of steroid hormones on regenerating tubules a realistic culture system is of great importance. An advanced technique creates an artificial interstitium promoting renal stem/progenitor cells to develop tubules between layers of polyester fleece. During perfusion culture with chemically defined Iscove’s Modified Dulbecco’s Medium (IMDM) individual steroid hormones can be administered. After a culture period of 13 days the effect.. Read More»
  DOI: 10.4172/2157-7552.1000101

  Abstract PDF