Germany
Research Article
Polyester Fleeces used as an Artificial Interstitium Influence the Spatial Growth of Regenerating Tubules
Author(s): Will W. Minuth, Anne Glashauser and Lucia DenkWill W. Minuth, Anne Glashauser and Lucia Denk
In regenerative medicine the use of stem/progenitor cells is a valuable therapeutical option for the regeneration of diseased tissues and organs. However, the secure application of cell-based therapies for the treatment of renal failure requires exact information regarding the mechanisms of parenchyma development in combination with different kinds of biomaterials. Recently, we demonstrated that application of stem/progenitor cells in combination with a polyester fleece I-7 as an artificial interstitium supported the spatial generation of tubules during perfusion culture in chemically defined Iscove`s Modified Dulbecco’s Medium containing aldosterone (1x10-7M). In the present experiments we investigated if the use of different polyester fleeces (Posi-4 and Posi-5 in comparison to I-7) has any effect on generation, differentiation and spatial dev.. Read More»
DOI:
10.4172/2157-7552.1000105
Journal of Tissue Science and Engineering received 807 citations as per Google Scholar report