Nuclear Medicine & Radiation Therapy

Annelie Johansson

Publications

• Research Article
  A Biologically Conformal Intensity-Modulated Radiotherapy Framework Based on [18F] Fluoro-Deoxy-Glucose Positron Emission Tomography for Individualized Cancer Treatment
  Author(s): Annelie Johansson, Camilo J. Sanz Freire, Pedro M. Collado Chamorro, Susana Pérez Echagüen, Gustavo A. Ossola Lentati and Alejandro Sánchez-CrespoAnnelie Johansson, Camilo J. Sanz Freire, Pedro M. Collado Chamorro, Susana Pérez Echagüen, Gustavo A. Ossola Lentati and Alejandro Sánchez-Crespo
  
  Purpose: To develop a framework for biologically-optimized routine intensity modulated radiotherapy (IMRT) treatment plans based on 18F-fluoro-deoxy-glucose (FDG)-Positron Emission Tomography (PET)/Computed Tomography imaging. Methods and materials: The dose-planning FDG-PET images are first corrected for partial volume effect using an iterative algorithm with a noise suppression filter. Thereafter, the FDG-uptake is used for transforming the delineated clinical target volume (CTV) into a set of biological planning target volumes (bPTV). This is done with an optimization algorithm that groups pixel values with the objective of maximizing the FDG-uptake variance between bPTV. The resulting average FDG pixel intensity within each bPTV, together with a tumor control probability (TCP) function, are used to obtain the prescribed dose to each bPTV .. Read More»
  DOI: 10.4172/2155-9619.1000171

  Abstract PDF