Journal of Hypertension: Open Access

Annette Ives

Publications

• Research Article
  Renin-Dependent Hypertension in Mice Requires the NLRP3- Inflammasome
  Author(s): Qing Wang, Alexander So, Jürg Nussberger, Annette Ives, Nathaliane Bagnoud, Stephan Shäefer, Jürg Tschopp and Michel BurnierQing Wang, Alexander So, Jürg Nussberger, Annette Ives, Nathaliane Bagnoud, Stephan Shäefer, Jürg Tschopp and Michel Burnier
  
  Objective: Recent studies have implicated an enhanced secretion of IL1β through activation of the Nod-like receptor family, pyrin domain containing 3 (Nlrp3)-inflammasome as the pro-inflammatory signal in animal models of the gout, chronic kidney disease (CKD), atherosclerosis, metabolic syndrome, type 2 diabetes mellitus, but its contribution to hypertension is not established. We aimed to demonstrate the role of the Nlrp3-inflammasome in the two-kidneys, one clip (2K1C) Goldblatt model of hypertension in Nlrp3-/- and apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc)-/- and wild type control male mice. Study design: 2K1C hypertension was generated by narrowing left renal artery using U-shaped stainless steel clip. BP and heart rate were recorded intra-arterially with a computerized data-acquisition s.. Read More»
  

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